The potential of metabolic imaging Journal Article
| Authors: | Gialleonardo, V. D.; Wilson, D. M.; Keshari, K. R. |
| Article Title: | The potential of metabolic imaging |
| Abstract: | Metabolic imaging is a field of molecular imaging that focuses and targets changes in metabolic pathways for the evaluation of different clinical conditions. Targeting and quantifying metabolic changes noninvasively is a powerful approach to facilitate diagnosis and evaluate therapeutic response. This review addresses only techniques targeting metabolic pathways. Other molecular imaging strategies, such as affinity or receptor imaging or microenvironment-dependent methods are beyond the scope of this review. Here we describe the current state of the art in clinically translatable metabolic imaging modalities. Specifically, we focus on PET and MR spectroscopy, including conventional 1H- and 13C-MR spectroscopy at thermal equilibrium and hyperpolarized MRI. In this article, we first provide an overview of metabolic pathways that are altered in many pathologic conditions and the corresponding probes and techniques used to study those alterations. We then describe the application of metabolic imaging to several common diseases, including cancer, neurodegeneration, cardiac ischemia, and infection or inflammation. © 2016 Elsevier Inc. |
| Keywords: | nonhuman; cancer staging; neuroimaging; positron emission tomography; brain tumor; infection; breast cancer; inflammation; molecular imaging; prostate cancer; heart failure; fluorodeoxyglucose f 18; choline; reactive oxygen metabolite; creatine kinase; adenosine triphosphate; parkinson disease; multiple sclerosis; glutamic acid; glucose oxidation; glycolysis; alzheimer disease; radiation necrosis; glutamine; methionine; heart muscle ischemia; proton nuclear magnetic resonance; nicotinamide adenine dinucleotide; methionine c 11; metabolic imaging; nerve degeneration; carbon nuclear magnetic resonance; pyruvate dehydrogenase; traumatic brain injury; cardiac imaging; glucose transporter; brain metabolism; amino acid metabolism; acetyl coenzyme a; hexokinase; tricarboxylic acid; human; article; heart muscle metabolism; gallium citrate; glucose 6 phosphate |
| Journal Title: | Seminars in Nuclear Medicine |
| Volume: | 46 |
| Issue: | 1 |
| ISSN: | 0001-2998 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-01-01 |
| Start Page: | 28 |
| End Page: | 39 |
| Language: | English |
| DOI: | 10.1053/j.semnuclmed.2015.09.004 |
| PROVIDER: | scopus |
| PMCID: | PMC4686865 |
| PUBMED: | 26687855 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 February 2016 -- Source: Scopus |
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