Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for non-endemic nasopharyngeal carcinoma Journal Article
| Authors: | Setton, J.; Han, J.; Kannarunimit, D.; Wuu, Y. R.; Rosenberg, S. A.; Deselm, C.; Wolden, S. L.; Tsai, C. J.; McBride, S. M.; Riaz, N.; Lee, N. Y. |
| Article Title: | Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for non-endemic nasopharyngeal carcinoma |
| Abstract: | Background We report treatment outcomes for a large non-endemic cohort of patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) and chemotherapy. Methods We identified 177 consecutive patients with newly diagnosed, non-metastatic nasopharyngeal cancer treated with definitive IMRT between 1998 and 2011. Endpoints included local, regional, distant control, and overall survival. Results Median follow-up was 52 months. The 3-/5-year actuarial rates of local control, regional control, distant control, and overall survival were 92%/83%, 93%/91%, 86%/83%, and 87%/74%, respectively. The median time to local recurrence was 30 months; the annual hazard of local recurrence did not diminish until the 6th year of follow-up. Conclusions Overall, we observed excellent rates of disease control and survival consistent with initially reported results from our institution. Attaining locoregional control in patients with extensive primary tumors remains a significant clinical challenge. With mature follow-up we observed that more than half of observed local relapses occurred after 2 years, a pattern distinct from that of carcinomas arising from other head and neck sites. These findings raise the possibility that patients with NPC may benefit from close follow-up during post-treatment years 3-5. © 2015 Elsevier Ltd. All rights reserved.All rights reserved. |
| Keywords: | radiotherapy; imrt; nasopharyngeal carcinoma; clinical outcomes |
| Journal Title: | Oral Oncology |
| Volume: | 53 |
| ISSN: | 1368-8375 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2016-02-01 |
| Start Page: | 67 |
| End Page: | 73 |
| Language: | English |
| DOI: | 10.1016/j.oraloncology.2015.11.015 |
| PROVIDER: | scopus |
| PUBMED: | 26675283 |
| PMCID: | PMC4975930 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 February 2016 -- Source: Scopus |
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