Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for non-endemic nasopharyngeal carcinoma Journal Article


Authors: Setton, J.; Han, J.; Kannarunimit, D.; Wuu, Y. R.; Rosenberg, S. A.; Deselm, C.; Wolden, S. L.; Tsai, C. J.; McBride, S. M.; Riaz, N.; Lee, N. Y.
Article Title: Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for non-endemic nasopharyngeal carcinoma
Abstract: Background We report treatment outcomes for a large non-endemic cohort of patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy (IMRT) and chemotherapy. Methods We identified 177 consecutive patients with newly diagnosed, non-metastatic nasopharyngeal cancer treated with definitive IMRT between 1998 and 2011. Endpoints included local, regional, distant control, and overall survival. Results Median follow-up was 52 months. The 3-/5-year actuarial rates of local control, regional control, distant control, and overall survival were 92%/83%, 93%/91%, 86%/83%, and 87%/74%, respectively. The median time to local recurrence was 30 months; the annual hazard of local recurrence did not diminish until the 6th year of follow-up. Conclusions Overall, we observed excellent rates of disease control and survival consistent with initially reported results from our institution. Attaining locoregional control in patients with extensive primary tumors remains a significant clinical challenge. With mature follow-up we observed that more than half of observed local relapses occurred after 2 years, a pattern distinct from that of carcinomas arising from other head and neck sites. These findings raise the possibility that patients with NPC may benefit from close follow-up during post-treatment years 3-5. © 2015 Elsevier Ltd. All rights reserved.All rights reserved.
Keywords: radiotherapy; imrt; nasopharyngeal carcinoma; clinical outcomes
Journal Title: Oral Oncology
Volume: 53
ISSN: 1368-8375
Publisher: Elsevier Inc.  
Date Published: 2016-02-01
Start Page: 67
End Page: 73
Language: English
DOI: 10.1016/j.oraloncology.2015.11.015
PROVIDER: scopus
PUBMED: 26675283
PMCID: PMC4975930
DOI/URL:
Notes: Article -- Export Date: 3 February 2016 -- Source: Scopus
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MSK Authors
  1. Suzanne L Wolden
    448 Wolden
  2. Nadeem Riaz
    249 Riaz
  3. Nancy Y. Lee
    601 Lee
  4. Jeremy Setton
    70 Setton
  5. Carl J Deselm
    17 Deselm
  6. Sean Matthew McBride
    149 McBride
  7. James Edward Han
    6 Han
  8. Chiaojung Jillian   Tsai
    115 Tsai
  9. Yen-Ruh   Wuu
    2 Wuu
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