Intensity-modulated radiotherapy in postoperative treatment of oral cavity cancers Journal Article
| Authors: | Gomez, D. R.; Zhung, J. E.; Gomez, J.; Chan, K.; Wu, A. J.; Wolden, S. L.; Pfister, D. G.; Shaha, A.; Shah, J. P.; Kraus, D. H.; Wong, R. J.; Lee, N. Y. |
| Article Title: | Intensity-modulated radiotherapy in postoperative treatment of oral cavity cancers |
| Abstract: | Purpose: To present our single-institution experience of intensity-modulated radiotherapy (IMRT) for oral cavity cancer. Methods and Materials: Between September 2000 and December 2006, 35 patients with histologically confirmed squamous cell carcinoma of the oral cavity underwent surgery followed by postoperative IMRT. The sites included were buccal mucosa in 8, oral tongue in 11, floor of the mouth in 9, gingiva in 4, hard palate in 2, and retromolar trigone in 1. Most patients had Stage III-IV disease (80%). Ten patients (29%) also received concurrent postoperative chemotherapy with IMRT. The median prescribed radiation dose was 60 Gy. Results: The median follow-up for surviving patients was 28.1 months (range, 11.9-85.1). Treatment failure occurred in 11 cases as follows: local in 4, regional in 2, and distant metastases in 5. Of the 5 patients with distant metastases, 2 presented with dermal metastases. The 2- and 3-year estimates of locoregional progression-free survival, distant metastasis-free survival, disease-free survival, and overall survival were 84% and 77%, 85% and 85%, 70% and 64%, and 74% and 74%, respectively. Acute Grade 2 or greater dermatitis, mucositis, and esophageal reactions were experienced by 54%, 66%, and 40% of the patients, respectively. Documented late complications included trismus (17%) and osteoradionecrosis (5%). Conclusion: IMRT as an adjuvant treatment after surgical resection for oral cavity tumors is feasible and effective, with promising results and acceptable toxicity. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | adult; cancer chemotherapy; cancer survival; aged; middle aged; cancer surgery; treatment failure; retrospective studies; major clinical study; overall survival; histopathology; cancer localization; intensity modulated radiation therapy; neck dissection; squamous cell carcinoma; carcinoma, squamous cell; cisplatin; fluorouracil; multimodality cancer therapy; antineoplastic agents; paclitaxel; cancer adjuvant therapy; disease free survival; postoperative care; radiation dose; radiotherapy, adjuvant; chemotherapy; cancer staging; outcome assessment; follow up; carboplatin; progression free survival; esophagitis; mucosa inflammation; radiotherapy dosage; radiotherapy; kidney failure; pathology; retrospective study; cetuximab; distant metastasis; prescription; imrt; intensity-modulated radiotherapy; physical therapy; radiotherapy, intensity-modulated; radiation injuries; xerostomia; disease free interval; dermatitis; drug substitution; overall survivals; mouth neoplasms; trismus; oral cavity; postoperative radiotherapy; adjuvant treatments; buccal mucosas; disease-free survivals; mucositis; oral cavity tumors; osteoradionecrosis; progression-free survivals; squamous cell carcinomas; surgical resections; treatment failures; bone necrosis; cheek mucosa; gingiva; gingiva tumor; hard palate; hearing impairment; local metastasis; maxilla resection; molar tooth; mouth; mouth cancer; oral surgery; regional metastasis; skin metastasis; tongue carcinoma |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 73 |
| Issue: | 4 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-03-15 |
| Start Page: | 1096 |
| End Page: | 1103 |
| Language: | English |
| DOI: | 10.1016/j.ijrobp.2008.05.024 |
| PUBMED: | 18707827 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 30 November 2010" - "CODEN: IOBPD" - "Source: Scopus" |
