Advances and concepts in cervical cancer trials: A road map for the future Journal Article


Authors: Sagae, S.; Monk, B. J.; Pujade-Lauraine, E.; Gaffney, D. K.; Narayan, K.; Ryu, S. Y.; McCormack, M.; Plante, M.; Casado, A.; Reuss, A.; Chávez-Blanco, A.; Kitchener, H.; Nam, B. H.; Jhingran, A.; Temkin, S.; Mileshkin, L.; Berns, E.; Scholl, S.; Doll, C.; Abu-Rustum, N. R.; Lecuru, F.; Small, W.; On behalf of the participants of the Gynecologic Cancer InterGroup Cervix Cancer brainstorming day
Article Title: Advances and concepts in cervical cancer trials: A road map for the future
Abstract: Objective Cervical cancer is responsible for more than a quarter of a million deaths globally each year, mostly in developing countries, making therapeutic advances in all health care settings a top priority. The Gynecologic Cancer InterGroup (GCIG) is a worldwide collaboration of leading national research groups that develops and promotes multinational trials in gynecologic cancer. In recognition of the pressing need for action, the GCIG convened an international meeting with expert representation from the GCIG groups and selected large sites in low-and middle-income countries. Methods The focus was to develop a consensus on several concepts for future clinical trials, which would be developed and promoted by the GCIG and launched with major international participation. The first half of the meeting was devoted to a resume of the current state of the knowledge and identifying the gaps in need of new evidence, validating control arms for present and future clinical trials and identifying national and international barriers for studies of cervix cancers. The second half of the meeting was concerned with achieving consensus on a path forward. Results and Conclusions There were 5 principal outcomes as follows: first, a proposal to expand fertility-preserving options with neoadjuvant chemotherapy; second, validation of the assessment of sentinel lymph nodes using minimally invasive surgery with an emphasis on identification and management of low-volume metastasis, such as isolated tumor cells and micrometastasis; third, evaluation of hypofractionation for palliative and curative radiation under the umbrella of the GCIG Cervix Cancer Research Network; fourth, adding to the advances in antiangiogenesis therapy in the setting of metastatic disease; and fifth, developing a maintenance study among women at high risk of relapse. The latter 2 systemic interventions could study PI3K (phosphatidylinositol-3-kinase) inhibitors, immunotherapy, anti-human papillomavirus approaches, or novel antiangiogenic agents/combinations. © 2015 by IGCS AND ESGO.
Keywords: clinical trials; cervical cancer; gcig; gynecologic cancer intergroup
Journal Title: International Journal of Gynecological Cancer
Volume: 26
Issue: 1
ISSN: 1048-891X
Publisher: Lippincott Williams & Wilkins  
Date Published: 2016-01-01
Start Page: 199
End Page: 207
Language: English
DOI: 10.1097/igc.0000000000000587
PROVIDER: scopus
PUBMED: 26569057
PMCID: PMC4831060
DOI/URL:
Notes: Conference Paper -- Presented at the Gynecologic Cancer InterGroup Cervix Cancer Brainstorming Day, Melbourne, Australia, November 6, 2014 -- Export Date: 3 February 2016 -- Source: Scopus
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