The development of priority cervical cancer trials: A Gynecologic Cancer InterGroup report Journal Article
| Authors: | Kitchener, H. C.; Hoskins, W.; Small, W. Jr; Thomas, G. M.; Trimble, E. L. |
| Article Title: | The development of priority cervical cancer trials: A Gynecologic Cancer InterGroup report |
| Abstract: | Since the late 1990s, when a spate of US studies reported the benefit of chemoradiation for cervical cancer, there has been a dearth of clinical trials in cervical cancer. This requires to be addressed with urgency because this disease is responsible for a quarter of a million deaths globally each year, mostly in developing countries, but therapeutic advances are required in all health care settings. The Gynecologic Cancer InterGroup (GCIG) is a worldwide collaborative of leading national groups that develops and promotes multinational trials in gynecologic cancer. In recognition of the pressing need for action, the GCIG convened an international meeting with expert representations from most of the GCIG groups and selected large centers in low- and middle-income countries. The focus was to identify consensus on several concepts for clinical trials, which would be developed and promoted by the GCIG and launched with major international participation. The first half of the meeting was devoted to a resume of the current state of the knowledge and identifying the gaps most needing new evidence. The second half of the meeting was concerned with achieving consensus on the way forward. There were 2 principal outcomes. The first was a proposal to establish, under the umbrella of GCIG, a cervical cancer trials network of centers from countries currently outside GCIG (Eastern Europe, India, Thailand, Southern Africa, and South and Central America), which could increase international participation in trials, conducted within the principles of good clinical practice. The second was to identify the priorities for clinical trials. These included additional systemic therapy before or after chemoradiation; less radical surgery for small, early-stage tumors; the use of fewer fractions to improve cost-effectiveness of treatment in centers with limited resources; and chemotherapy to improve resectability of bulky tumors. Copyright © 2010 by IGCS and ESGO. |
| Keywords: | cancer chemotherapy; protein expression; treatment outcome; survival analysis; cancer surgery; clinical trial; review; bevacizumab; cisplatin; fluorouracil; cancer combination chemotherapy; unspecified side effect; gemcitabine; paclitaxel; cancer radiotherapy; chemotherapy, adjuvant; combined modality therapy; neoadjuvant therapy; radiotherapy, adjuvant; topotecan; cancer staging; human immunodeficiency virus infection; recurrent cancer; antineoplastic agent; cancer incidence; hysterectomy; neoplasm staging; clinical practice; carboplatin; protein p16; multiple cycle treatment; neoplasm recurrence, local; imiquimod; antineoplastic combined chemotherapy protocols; randomized controlled trials as topic; cancer screening; vincristine; radiation injury; tumor marker; cancer mortality; ifosfamide; vinblastine; carcinogenesis; europe; cost effectiveness analysis; societies, medical; uterine cervix cancer; practice guidelines as topic; cediranib; medical society; brachytherapy; bleomycin; stomach cancer; liver cancer; india; antiretrovirus agent; highly active antiretroviral therapy; hyperthermic therapy; uterine cervical neoplasms; radical hysterectomy; international cooperation; wart virus; uterine cervix carcinoma in situ; trials; wart virus vaccine; cancer of the cervix; oncostatin m receptor; central america; south africa; south america; thailand |
| Journal Title: | International Journal of Gynecological Cancer |
| Volume: | 20 |
| Issue: | 6 |
| ISSN: | 1048-891X |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2010-08-01 |
| Start Page: | 1092 |
| End Page: | 1100 |
| Language: | English |
| DOI: | 10.1111/IGC.0b013e3181e730aa |
| PUBMED: | 20683424 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: IJGCE" - "Source: Scopus" |
