Preoperative Therapy for Esophageal Cancer Journal Article
| Authors: | Ku, G. Y.; Ilson, D. H. |
| Article Title: | Preoperative Therapy for Esophageal Cancer |
| Abstract: | This article examines the role of combined-modality therapy for treating locally advanced esophageal cancer. Although surgery remains a cornerstone of treatment, recent studies have demonstrated that pre- or perioperative chemotherapy is associated with improved survival for patients who have adenocarcinoma histology. Primary chemoradiotherapy is the accepted standard of care for medically inoperable patients. Recent studies also suggest that definitive chemoradiotherapy is acceptable for patients who have squamous histology, while subsequent surgery improves local control without conferring a clear survival benefit. Neoadjuvant chemoradiotherapy continues to be investigated but is associated with several advantages over neoadjuvant chemotherapy alone, including an improvement in the pathologic complete response rate and resectability. Patients who achieve a pathologic complete response also appear to have improved survival. Adjuvant chemoradiotherapy may be considered for patients who undergo primary resection of lower esophageal/gastroesophageal junction adenocarcinoma. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; cancer survival; treatment response; clinical trial; histopathology; review; bevacizumab; cisplatin; fluorouracil; unspecified side effect; capecitabine; paclitaxel; cancer adjuvant therapy; cancer radiotherapy; preoperative care; neoadjuvant therapy; chemotherapy; positron emission tomography; carboplatin; multiple cycle treatment; etoposide; continuous infusion; cetuximab; irinotecan; clinical trials, phase iii as topic; folinic acid; fluorodeoxyglucose f 18; bleomycin; epirubicin; vindesine; mitomycin; oxaliplatin; esophagus cancer; esophageal neoplasms; pet scan; chemoradiotherapy; esophageal cancer; preoperative therapy; lower esophagus sphincter |
| Journal Title: | Gastroenterology Clinics of North America |
| Volume: | 38 |
| Issue: | 1 |
| ISSN: | 0889-8553 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-03-01 |
| Start Page: | 135 |
| End Page: | 152 |
| Language: | English |
| DOI: | 10.1016/j.gtc.2009.01.012 |
| PUBMED: | 19327572 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 30 November 2010" - "CODEN: GCNAE" - "Source: Scopus" |
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