Role of Neoadjuvant Therapy for Esophageal Adenocarcinoma Journal Article
| Authors: | Ku, G. Y.; Ilson, D. H. |
| Article Title: | Role of Neoadjuvant Therapy for Esophageal Adenocarcinoma |
| Abstract: | This article examines the role of neoadjuvant therapy in the treatment of locally advanced esophageal adenocarcinoma. Recent studies have demonstrated that pre- or perioperative chemotherapy is associated with improved survival. Neoadjuvant chemoradiotherapy continues to be investigated but is associated with several advantages over neoadjuvant chemotherapy alone. Primary chemoradiotherapy is the accepted standard of care for medically inoperable patients, whereas adjuvant chemoradiotherapy may be considered for patients who undergo primary resection of lower esophageal/gastroesophageal junction tumors. Future directions include the investigation of newer chemotherapy regimens, the addition of targeted therapies, and the use of position emission tomography to provide an early assessment of response. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | cancer survival; treatment outcome; treatment response; cancer surgery; survival rate; overall survival; clinical trial; drug tolerability; histopathology; review; cancer recurrence; squamous cell carcinoma; bevacizumab; cisplatin; fluorouracil; cancer combination chemotherapy; drug efficacy; multimodality cancer therapy; unspecified side effect; capecitabine; paclitaxel; cancer adjuvant therapy; cancer patient; cancer radiotherapy; postoperative care; preoperative care; radiation dose; combined modality therapy; neoadjuvant therapy; radiotherapy, adjuvant; chemotherapy; positron emission tomography; neoplasm staging; adenocarcinoma; carboplatin; multiple cycle treatment; bone marrow suppression; etoposide; esophagitis; mucosa inflammation; nausea; antineoplastic combined chemotherapy protocols; evidence-based practice; continuous infusion; cetuximab; vinblastine; radiation response; irinotecan; clinical trials, phase iii as topic; folinic acid; fluorodeoxyglucose f 18; positron-emission tomography; stomach cancer; epirubicin; therapy effect; perioperative period; mitomycin; esophagus cancer; esophageal adenocarcinoma; stomach adenocarcinoma; esophageal neoplasms; esophagectomy; chemoradiotherapy; esophageal squamous cell carcinoma; esophageal; gastroesophageal |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 18 |
| Issue: | 3 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-01-01 |
| Start Page: | 533 |
| End Page: | 546 |
| Language: | English |
| DOI: | 10.1016/j.soc.2009.03.004 |
| PUBMED: | 19500742 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "CODEN: SOCAF" - "Source: Scopus" |
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