Creating patient-specific neural cells for the in vitro study of brain disorders Journal Article
| Authors: | Brennand, K. J.; Marchetto, M. C.; Benvenisty, N.; Brüstle, O.; Ebert, A.; Izpisua Belmonte, J. C.; Kaykas, A.; Lancaster, M. A.; Livesey, F. J.; McConnell, M. J.; McKay, R. D.; Morrow, E. M.; Muotri, A. R.; Panchision, D. M.; Rubin, L. L.; Sawa, A.; Soldner, F.; Song, H.; Studer, L.; Temple, S.; Vaccarino, F. M.; Wu, J.; Vanderhaeghen, P.; Gage, F. H.; Jaenisch, R. |
| Article Title: | Creating patient-specific neural cells for the in vitro study of brain disorders |
| Abstract: | As a group, we met to discuss the current challenges for creating meaningful patient-specific in vitro models to study brain disorders. Although the convergence of findings between laboratories and patient cohorts provided us confidence and optimism that hiPSC-based platforms will inform future drug discovery efforts, a number of critical technical challenges remain. This opinion piece outlines our collective views on the current state of hiPSC-based disease modeling and discusses what we see to be the critical objectives that must be addressed collectively as a field. © 2015 The Authors. |
| Keywords: | nonhuman; conference paper; gene expression; embryonic stem cell; astrocyte; neural stem cell; in vitro study; transgene; brain disease; pluripotent stem cell; nervous system development; nerve cell; mitochondrion; mood disorder; nuclear reprogramming; genetic polymorphism; blastocyst; motoneuron; ectoderm; single cell analysis; germ layer; mosaicism; brain tissue; bipolar disorder; spinal muscular atrophy; human; priority journal |
| Journal Title: | Stem Cell Reports |
| Volume: | 5 |
| Issue: | 6 |
| ISSN: | 2213-6711 |
| Publisher: | Cell Press |
| Date Published: | 2015-12-08 |
| Start Page: | 933 |
| End Page: | 945 |
| Language: | English |
| DOI: | 10.1016/j.stemcr.2015.10.011 |
| PROVIDER: | scopus |
| PUBMED: | 26610635 |
| PMCID: | PMC4881284 |
| DOI/URL: | |
| Notes: | Export Date: 15 January 2016 -- Conference Paper -- Source: Scopus |
