Pluripotent stem cell-based disease modeling: Current hurdles and future promise Journal Article
| Authors: | Zeltner, N.; Studer, L. |
| Article Title: | Pluripotent stem cell-based disease modeling: Current hurdles and future promise |
| Abstract: | Human induced pluripotent stem cells (hiPSCs) can yield unlimited numbers of patient-specific cells of any type and may be an important tool in efforts to overcome current shortcomings in biomedical research. In vitro disease models based on the use of hiPSCs have been proposed for various applications. Those include drug discovery and validation, efficacy, safety and toxicity assays, the elucidation of previously unknown disease mechanisms, the enhancement of animal based assays, the promise of conducting clinical trials in the dish and the identification of cell types and stages suitable for cell replacement therapies. Here, we provide an overview of the current state of hiPSC-based disease modeling and discuss recent progress and remaining challenges on the road to realizing the full potential of this novel technology. © 2015. |
| Keywords: | review; drug efficacy; nonhuman; cell maturation; cell differentiation; in vitro study; disease model; toxicity testing; cytoplasm; cell therapy; pluripotent stem cell; valproic acid; cell stress; nuclear reprogramming; sampling; personalized medicine; clinical trial (topic); human; priority journal; kenpaullone; dexpramipexole; olesoxime; retigabine |
| Journal Title: | Current Opinion in Cell Biology |
| Volume: | 37 |
| ISSN: | 0955-0674 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-12-01 |
| Start Page: | 102 |
| End Page: | 110 |
| Language: | English |
| DOI: | 10.1016/j.ceb.2015.10.008 |
| PROVIDER: | scopus |
| PUBMED: | 26629748 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 7 January 2016 -- Source: Scopus |
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