Observational methods to assess the effectiveness of screening colonoscopy in reducing right colon cancer mortality risk: SCOLAR Journal Article
| Authors: | Goodman, M.; Fletcher, R. H.; Doria-Rose, V. P.; Jensen, C. D.; Zebrowski, A. M.; Becerra, T. A.; Quinn, V. P.; Zauber, A. G.; Corley, D. A.; Doubeni, C. A. |
| Article Title: | Observational methods to assess the effectiveness of screening colonoscopy in reducing right colon cancer mortality risk: SCOLAR |
| Abstract: | Aims: Screening colonoscopy's effectiveness in reducing risk of death from right colon cancers remains unclear. Methodological challenges of existing observational studies addressing this issue motivated the design of 'Effectiveness of Screening for Colorectal Cancer in Average-Risk Adults (SCOLAR)'. Methods: SCOLAR is a nested case-control study based on two large integrated health systems. This affords access to a large, well-defined historical cohort linked to integrated data on cancer outcomes, patient eligibility, test indications and important confounders. Results: We found electronic data adequate for excluding ineligible patients (except family history), but not the detailed information needed for test indication assignment. Conclusion: The lessons of SCOLAR's design and implementation may be useful for future studies seeking to evaluate the effectiveness of screening tests in community settings. © 2015 Future Medicine Ltd. |
| Keywords: | case control study; cancer localization; cancer staging; colorectal cancer; quality control; cohort analysis; cancer screening; cancer mortality; electronic medical record; colonoscopy; colon cancer; observational study; sigmoidoscopy; feces analysis; selection bias; randomized controlled trial (topic); confounding variable; case-control study; human; priority journal; article |
| Journal Title: | Journal of Comparative Effectiveness Research |
| Volume: | 4 |
| Issue: | 6 |
| ISSN: | 2042-6305 |
| Publisher: | Future Medicine |
| Date Published: | 2015-01-01 |
| Start Page: | 541 |
| End Page: | 551 |
| Language: | English |
| DOI: | 10.2217/cer.15.39 |
| PROVIDER: | scopus |
| PMCID: | PMC4666780 |
| PUBMED: | 26201973 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 7 January 2016 -- 541 -- Source: Scopus |
