Long-term survival with salvage surgery for recurrent esophageal adenocarcinoma after chemoradiotherapy Journal Article


Authors: Ku, G. Y.; Ilson, D. H.
Article Title: Long-term survival with salvage surgery for recurrent esophageal adenocarcinoma after chemoradiotherapy
Abstract: The patient is an 80-year-old man with a newly diagnosed gastroesophageal junction adenocarcinoma, whose comorbidities include coronary artery disease, percutaneous coronary intervention 3 years earlier without recurrence of chest pain, and well-controlled diabetes. He is otherwise healthy and lives independently with his elderly wife. Baseline staging by [18F]fluorodeoxyglucose-positron emission tomography (PET)/computed tomography (CT) scan and endoscopic ultrasound reveal a uT3N0 tumor without evidence of metastasis.Heis treated with induction carboplatin plus paclitaxel, and repeat PET/CT scan demonstrates >35% decrease in maximum standardized uptake value of the primary tumor. He then receives concurrent chemoradiation with carboplatin plus paclitaxel to a total of 50.4 Gy. Repeat PET/CT reveals complete resolution of prior abnormal [18F]fluorodeoxyglucose uptake, and endoscopy indicates only mild mucosal irregularity at the site of the prior tumor, biopsy of which is negative for cancer. The patient is concerned about the risks of surgery and wishes to avoid it if possible. He returns to discuss further management. © 2015 by American Society of Clinical Oncology.
Keywords: cancer survival; aged; cancer surgery; primary tumor; cancer recurrence; case report; salvage therapy; multimodality cancer therapy; paclitaxel; cancer diagnosis; carboplatin; thorax pain; diabetes mellitus; fluorodeoxyglucose f 18; computer assisted emission tomography; medical literature; esophageal adenocarcinoma; endoscopy; coronary artery disease; chemoradiotherapy; endoscopic echography; lower esophagus sphincter; randomized controlled trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); percutaneous coronary intervention; long term survival; very elderly; human; male; priority journal; article
Journal Title: Journal of Clinical Oncology
Volume: 33
Issue: 33
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2015-11-20
Start Page: 3854
End Page: 3857
Language: English
DOI: 10.1200/JCO.2015.62.6796
PROVIDER: scopus
PUBMED: 26324375
DOI/URL:
Notes: Article -- Export Date: 7 January 2016 -- 3854 -- Source: Scopus
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MSK Authors
  1. Geoffrey Yuyat Ku
    86 Ku
  2. David H Ilson
    269 Ilson