Analytical performance of the Abaxis Piccolo Xpress® point of care analyzer in whole blood, serum, and plasma Journal Article

Authors: Murata, K.; Glaser, L.; Nardiello, M.; Richardson, S.; Ramanathan, L. V.; Carlow, D. C.
Article Title: Analytical performance of the Abaxis Piccolo Xpress® point of care analyzer in whole blood, serum, and plasma
Abstract: Objectives: To examine the analytical performance of 14 comprehensive metabolic panel analytes on the Abaxis Piccolo Xpress® Point of Care analyzer in serum, plasma, and whole blood. Design and methods: Precision was evaluated by running two levels of control material over multiple days. Linearity was evaluated using material provided by the manufacturer and the College of American Pathologists (CAP) linearity surveys. Accuracy was evaluated by comparing the results from 60 patient specimens on the Piccolo Xpress® with the Ortho Vitros® 5600 analyzer. The method comparison was performed on all three specimen types intended for use on the Piccolo Xpress®: serum, heparinized plasma, and whole blood. Manufacturer suggested reference ranges for all 14 analytes were tested in serum and plasma specimens from 23 healthy volunteers. Results: High precision (CV?10%) was noted for all the analytes. Linearity was found to span the clinically useful range for all analytes. The method comparison demonstrated minimal proportional bias and good correlation for most of the analytes in all three matrices tested. The only exceptions were for sodium and total CO2, for which either significant proportional bias and/or poor correlation was noted in all three matrices. Significant bias was noted for AST in serum as well as for total bilirubin in plasma and whole blood. Conclusion: The Piccolo Xpress® allows for the delivery of CMP results in a footprint small enough to be stored in a biological safety cabinet, while providing satisfactory performance for the majority of analytes. © 2015 The Canadian Society of Clinical Chemists.
Keywords: accuracy; protein; calcium; creatinine; urea nitrogen blood level; alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; bilirubin; albumin; blood analysis; intermethod comparison; glucose; sodium; serum; plasma; amylase; normal human; whole blood; potassium; human experiment; chloride; point of care testing; hematology analyzer; human; priority journal; article; abaxis piccolo xpress; comprehensive metabolic panel; point-of-care
Journal Title: Clinical Biochemistry
Volume: 48
Issue: 18
ISSN: 0009-9120
Publisher: Elsevier Inc.  
Date Published: 2015-12-01
Start Page: 1344
End Page: 1346
Language: English
DOI: 10.1016/j.clinbiochem.2015.08.002
PROVIDER: scopus
PUBMED: 26255121
Notes: Article -- Export Date: 7 January 2016 -- 1344 -- Source: Scopus
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MSK Authors
  1. Kazunori Murata
    12 Murata
  2. Dean Christian Carlow
    20 Carlow