Author: | Marians, K. J. |
Article Title: | PriA-directed replication fork restart in Escherichia coli |
Abstract: | The encounter of a replication fork with either a damaged DNA template, a nick in the template strand or a 'frozen' protein-DNA complex can stall the replisome and cause it to fall apart. Such an event generates a requirement for replication fork restart if the cell is going to survive. Recent evidence shows that replication fork restart is effected by the action of the recombination proteins generating a substrate for PriA-directed replication fork assembly. Copyright (C) 2000 Elsevier Science Ltd. |
Keywords: | unclassified drug; dna-binding proteins; review; nonhuman; dna replication; chromosome; phenotype; dna damage; cell survival; escherichia coli; helicase; replication protein a; chromosomes, bacterial; reca protein; dna template; dna protein complex; priority journal; pria protein |
Journal Title: | Trends in Biochemical Sciences |
Volume: | 25 |
Issue: | 4 |
ISSN: | 0968-0004 |
Publisher: | Elsevier Inc. |
Date Published: | 2000-04-01 |
Start Page: | 185 |
End Page: | 189 |
Language: | English |
DOI: | 10.1016/s0968-0004(00)01565-6 |
PUBMED: | 10754552 |
PROVIDER: | scopus |
DOI/URL: | |
Notes: | Export Date: 18 November 2015 -- Source: Scopus |