Crawling and wiggling on DNA: Structural insights to the mechanism of DNA unwinding by helicases Journal Article
| Author: | Marians, K. J. |
| Article Title: | Crawling and wiggling on DNA: Structural insights to the mechanism of DNA unwinding by helicases |
| Abstract: | Crystal structures have recently been solved of the monomeric DNA helicase PcrA bound to forked DNA, and of the hexameric helicase domain of the bacteriophage T7 gene 4 protein, a replication fork DNA helicase/primase. These structures have led to the elaboration of the first molecular models to describe DNA helicase action. |
| Keywords: | gene translocation; protein domain; protein dna binding; structure-activity relationship; bacteria (microorganisms); bacterial protein; bacterial proteins; short survey; crystal structure; dna structure; computer simulation; models, molecular; helicase; dna, bacterial; dna helicases; molecular model; gene replication; dna primase; priority journal; bacteriophage t7 |
| Journal Title: | Structure |
| Volume: | 8 |
| Issue: | 12 |
| ISSN: | 0969-2126 |
| Publisher: | Cell Press |
| Date Published: | 2000-12-01 |
| Start Page: | R227 |
| End Page: | R235 |
| Language: | English |
| DOI: | 10.1016/s0969-2126(00)00539-6 |
| PUBMED: | 11188698 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
