Neoadjuvant therapy and surgical resection for locally advanced non-small cell lung cancer Journal Article
| Authors: | Meko, J.; Rusch, V. W. |
| Article Title: | Neoadjuvant therapy and surgical resection for locally advanced non-small cell lung cancer |
| Abstract: | During the past 15 years, treatment of stage IIIA (N2) non-small cell lung cancer has evolved considerably because of improvements in patients selection, staging, and combined modality therapy. Results of several clinical trials suggest that induction chemotherapy or chemoradiation and surgical resection is superior to surgery alone. However, the optimal induction regimen has not been defined. An intergroup trial is also underway to determine whether chemoradiation and surgical resection leads to better survival than chemotherapy and radiation alone. Future studies will assess ways to combine radiation and novel chemotherapeutic agents, and will identify molecular abnormalities that predict response to induction therapy. Copyright (C) 2000 by W.B. Saunders Company. |
| Keywords: | cancer survival; major clinical study; clinical trial; review; cisplatin; doxorubicin; fluorouracil; cancer combination chemotherapy; multimodality cancer therapy; gemcitabine; cancer adjuvant therapy; chemotherapy, adjuvant; neoadjuvant therapy; radiotherapy, adjuvant; cancer staging; nuclear magnetic resonance imaging; positron emission tomography; lymph node metastasis; antineoplastic agent; lymphatic metastasis; neoplasm staging; carboplatin; computer assisted tomography; phase 2 clinical trial; etoposide; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; lung cancer; cyclophosphamide; diagnostic imaging; radiation injury; ifosfamide; vinblastine; neoplasm metastasis; vindesine; phase 3 clinical trial; mitomycin; drug induced disease; taxol; taxotere; prognosis; human; priority journal |
| Journal Title: | Seminars in Radiation Oncology |
| Volume: | 10 |
| Issue: | 4 |
| ISSN: | 1053-4296 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2000-10-01 |
| Start Page: | 324 |
| End Page: | 332 |
| Language: | English |
| PUBMED: | 11040333 |
| PROVIDER: | scopus |
| DOI: | 10.1053/srao.2000.9128 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
