Resection of stage III non-small cell lung cancer following induction therapy Journal Article
| Author: | Rusch, V. W. |
| Article Title: | Resection of stage III non-small cell lung cancer following induction therapy |
| Abstract: | Approximately 25%-30% of all patients with non-small cell lung cancer (NSCLC) present with stage III tumors. Except for specific subsets, these tumors are not usually amenable to complete surgical resection and are associated with a 5-year survival of 10% or less. Because patients with stage III NSCLC die of distant metastases, recent efforts to improve the prognosis of these tumors have focused on neoadjuvant therapy using chemotherapy or chemoradiotherapy as induction treatment and subsequent surgical resection for local control. Many trials have now shown the feasibility of neoadjuvant therapy and suggest that overall survival is approximately double that seen after surgical resection or radiation alone. Future clinical trials will define whether surgical resection after induction therapy provides better local control and survival than chemotherapy and high-dose radiation alone. © 1995 Société Internationale de Chirurgie. |
| Keywords: | cancer chemotherapy; cancer survival; cancer surgery; survival rate; major clinical study; cisplatin; doxorubicin; conference paper; adjuvant therapy; cancer radiotherapy; combined modality therapy; cancer staging; neoplasm staging; etoposide; lung non small cell cancer; antineoplastic combined chemotherapy protocols; carcinoma, non-small-cell lung; lung neoplasms; cyclophosphamide; remission induction; cancer control; human |
| Journal Title: | World Journal of Surgery |
| Volume: | 19 |
| Issue: | 6 |
| ISSN: | 0364-2313 |
| Publisher: | Springer |
| Date Published: | 1995-11-01 |
| Start Page: | 817 |
| End Page: | 822 |
| Language: | English |
| DOI: | 10.1007/bf00299777 |
| PUBMED: | 8553672 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 28 August 2018 -- Source: Scopus |
