| Abstract: |
Our understanding of the morphologic and genetic features of renal epithelial neoplasia has brought about profound changes in the classification of these tumors. It is clear that they represent a heterogeneous group of tumors with distinct histopathologic, genetic, and clinical features ranging from benign to high-grade malignant. 'Granular' and 'sarcomatoid' carcinomas are not distinct entities, since tumors with granular or spindle cell features may be seen in many tumor-types. Using conventional pathologic tools such as hematoxylin and eosin staining, histochemistry, immunohistochemistry, and electron microscopy, we are able to properly classify the majority of these tumors. Nevertheless, approximately 6% to 7% of cases are impossible to classify in this fashion, thus requiring molecular genetic studies for proper characterization. Copyright (C) 2000 by W.B. Saunders Company. |
| Keywords: |
immunohistochemistry; clinical feature; review; neoplasm staging; cancer grading; electron microscopy; carcinoma, papillary; oncocytoma; kidney carcinoma; adenoma, oxyphilic; kidney neoplasms; kidney tumor; carcinoma, renal cell; neoplasms, germ cell and embryonal; tumor classification; carcinoma, medullary; neoplasms, glandular and epithelial; neoplasms, ductal, lobular, and medullary; kidney epithelium; kidney diseases, cystic; kidney tubules, collecting; humans; human; priority journal
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