Update on myogenic sarcomas Journal Article
| Author: | Agaram, N. P. |
| Article Title: | Update on myogenic sarcomas |
| Abstract: | Myogenic sarcomas include soft tissue sarcomas that show skeletal muscle differentiation (rhabdomyosarcoma) and those with smooth muscle differentiation (leiomyosarcoma). Rhabdomyosarcomas are more common in the pediatric age group and leiomyosarcomas occur more often in the adult population. Based on the clinico-pathologic features and genetic abnormalities identified, the rhabdomyosarcomas are classified into embryonal, alveolar, spindle cell/sclerosing, and pleomorphic subtypes. Each subtype shows distinctive morphology and has characteristic genetic abnormalities. In this update on myogenic sarcomas, each entity is discussed with special emphasis on recent updates in genetic findings and the diagnostic approach to these tumors. © 2018 Elsevier Inc. |
| Keywords: | gene mutation; clinical feature; histopathology; review; genetic analysis; tumor localization; differential diagnosis; risk assessment; gene identification; soft tissue sarcoma; age distribution; leiomyosarcoma; rhabdomyosarcoma; estrogen receptor; muscle tumor; embryonal; desmin; smooth muscle actin; alveolar; pleomorphic; abdominal tumor; caldesmon; foxo1; prognosis; human; priority journal; myod1 protein; myod1; pleomorphic rhabdomyosarcoma; sclerosing rhabdomyosarcoma; spindle cell rhabdomyosarcoma; spindle cell/sclerosing |
| Journal Title: | Surgical Pathology Clinics |
| Volume: | 12 |
| Issue: | 1 |
| ISSN: | 1875-9181 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2019-03-01 |
| Start Page: | 51 |
| End Page: | 62 |
| Language: | English |
| DOI: | 10.1016/j.path.2018.10.003 |
| PUBMED: | 30709448 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
