Update on myogenic sarcomas Journal Article


Author: Agaram, N. P.
Article Title: Update on myogenic sarcomas
Abstract: Myogenic sarcomas include soft tissue sarcomas that show skeletal muscle differentiation (rhabdomyosarcoma) and those with smooth muscle differentiation (leiomyosarcoma). Rhabdomyosarcomas are more common in the pediatric age group and leiomyosarcomas occur more often in the adult population. Based on the clinico-pathologic features and genetic abnormalities identified, the rhabdomyosarcomas are classified into embryonal, alveolar, spindle cell/sclerosing, and pleomorphic subtypes. Each subtype shows distinctive morphology and has characteristic genetic abnormalities. In this update on myogenic sarcomas, each entity is discussed with special emphasis on recent updates in genetic findings and the diagnostic approach to these tumors. © 2018 Elsevier Inc.
Keywords: gene mutation; clinical feature; histopathology; review; genetic analysis; tumor localization; differential diagnosis; risk assessment; gene identification; soft tissue sarcoma; age distribution; leiomyosarcoma; rhabdomyosarcoma; estrogen receptor; muscle tumor; embryonal; desmin; smooth muscle actin; alveolar; pleomorphic; abdominal tumor; caldesmon; foxo1; prognosis; human; priority journal; myod1 protein; myod1; pleomorphic rhabdomyosarcoma; sclerosing rhabdomyosarcoma; spindle cell rhabdomyosarcoma; spindle cell/sclerosing
Journal Title: Surgical Pathology Clinics
Volume: 12
Issue: 1
ISSN: 1875-9181
Publisher: Elsevier Inc.  
Date Published: 2019-03-01
Start Page: 51
End Page: 62
Language: English
DOI: 10.1016/j.path.2018.10.003
PUBMED: 30709448
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
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MSK Authors
  1. Narasimhan P Agaram
    122 Agaram