Toll signaling pathways in the innate immune response Journal Article
| Author: | Anderson, K. V. |
| Article Title: | Toll signaling pathways in the innate immune response |
| Abstract: | The Toll signaling pathway, which is required for the establishment of the dorsal-ventral axis in Drosophila embryos, plays an important role in the response of larval and adult Drosophila to microbial infections. Recent genetic evidence has shown that a mammalian Toll-like receptor, mouse Tlr4, is the signal transducing receptor activated by bacterial lipopolysaccharide. Thus, Toll-like receptors appear to detect a variety of microbial components and to trigger a defensive reaction in both Drosophila and mammals. Genetic data from both Drosophila and mice have defined components required for activation of Toll-like receptors and for the downstream pathways activated by the Toll-like receptors. |
| Keywords: | signal transduction; unclassified drug; review; nonhuman; mouse; animals; immune system; drosophila; immune response; membrane glycoproteins; lipopolysaccharide; receptor; mammals; bacterial infections; drosophila proteins; receptors, immunologic; receptors, cell surface; toll-like receptors; toll-like receptor 4; toll-like receptor 5; models, immunological; mycoses; immunogenetics; human; insect proteins; toll receptor |
| Journal Title: | Current Opinion in Immunology |
| Volume: | 12 |
| Issue: | 1 |
| ISSN: | 0952-7915 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2000-02-01 |
| Start Page: | 13 |
| End Page: | 19 |
| Language: | English |
| DOI: | 10.1016/s0952-7915(99)00045-x |
| PUBMED: | 10679407 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
