Replication and recombination intersect Journal Article
| Author: | Marians, K. J. |
| Article Title: | Replication and recombination intersect |
| Abstract: | A bacterial housekeeping function, which requires both recombination and replication enzymes, has been identified that re-establishes inactivated replication forks under normal growth conditions. Some long-tract gene-conversion events initiated by double-strand breaks in yeast and mammalian cells can be attributed to recombination-directed DNA replication. Double-strand break repair in yeast has been shown to require both leading- and lagging-strand DNA synthesis. These observations suggest that the recombination and replication machinery cooperate to maintain genomic integrity. |
| Keywords: | dna binding protein; review; nonhuman; dna replication; dna synthesis; dna recombination; mammalia; animals; bacteria (microorganisms); gene conversion; double stranded dna; recombination, genetic; mammal; yeast; dna, bacterial; bacterial genetics; housekeeping gene; humans; priority journal |
| Journal Title: | Current Opinion in Genetics and Development |
| Volume: | 10 |
| Issue: | 2 |
| ISSN: | 0959-437X |
| Publisher: | Elsevier Inc. |
| Date Published: | 2000-04-01 |
| Start Page: | 151 |
| End Page: | 156 |
| Language: | English |
| DOI: | 10.1016/s0959-437x(00)00059-9 |
| PUBMED: | 10753777 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
