Systemic chemotherapy Journal Article
| Authors: | Klimek, V. M.; Wolchok, J. D.; Chapman, P. B.; Houghton, A. N.; Hwu, W. J. |
| Article Title: | Systemic chemotherapy |
| Abstract: | The main use of systemic chemotherapy in metastatic melanoma remains palliative. Dacarbazine (dimethyl-1-triazeno imidazole-4-carboxamide [DTIC]) is the standard chemotherapy agent for advanced disease. The combination chemotherapy and biochemotherapy regimens have achieved higher response rates, but have not led to durable remission or improved survival. The field of systemic therapy remains in need of a more effective and less toxic treatment strategy. |
| Keywords: | cancer chemotherapy; cancer survival; survival rate; review; diarrhea; drug efficacy; drug safety; antineoplastic agents; paclitaxel; neoadjuvant therapy; temozolomide; palliative care; dacarbazine; melanoma; skin neoplasms; blood toxicity; nausea; vomiting; antineoplastic combined chemotherapy protocols; carmustine; lomustine; docetaxel; immunotherapy; remission induction; antineoplastic agents, hormonal; taxane derivative; nitrosourea derivative; humans; prognosis; human |
| Journal Title: | Clinics in Plastic Surgery |
| Volume: | 27 |
| Issue: | 3 |
| ISSN: | 0094-1298 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2000-07-01 |
| Start Page: | 451 |
| End Page: | 461 |
| Language: | English |
| PUBMED: | 10941565 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
