Breast cancer-derived extracellular vesicles: Characterization and contribution to the metastatic phenotype Journal Article


Authors: Green, T. M.; Alpaugh, M. L.; Barsky, S. H.; Rappa, G.; Lorico, A.
Article Title: Breast cancer-derived extracellular vesicles: Characterization and contribution to the metastatic phenotype
Abstract: The study of extracellular vesicles (EVs) in cancer progression is a complex and rapidly evolving field. Whole categories of cellular interactions in cancer which were originally presumed to be due solely to soluble secreted molecules have now evolved to include membrane-enclosed extracellular vesicles (EVs), which include both exosomes and shed microvesicles (MVs), and can contain many of the same molecules as those secreted in soluble form but many different molecules as well. EVs released by cancer cells can transfer mRNA, miRNA, and proteins to different recipient cells within the tumor microenvironment, in both an autocrine and paracrine manner, causing a significant impact on signaling pathways, mRNA transcription, and protein expression. The transfer of EVs to target cells, in turn, supports cancer growth, immunosuppression, and metastasis formation. This review focuses exclusively on breast cancer EVs with an emphasis on breast cancer-derived exosomes, keeping in mind that breast cancer-derived EVs share some common physical properties with EVs of other cancers. © 2015 Toni M. Green et al.
Journal Title: Biomed Research International
Volume: 2015
ISSN: 2314-6133
Publisher: Hindawi Publishing Corporation  
Date Published: 2015-01-01
Start Page: 634865
Language: English
DOI: 10.1155/2015/634865
PROVIDER: scopus
PMCID: PMC4639645
PUBMED: 26601108
DOI/URL:
Notes: Export Date: 2 December 2015 -- Source: Scopus
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  1. Mary Alpaugh
    19 Alpaugh