Comparing tumour staging and grading systems: A case study and a review of the issues, using thymoma as a model Journal Article
| Authors: | Begg, C. B.; Cramer, L. D.; Venkatraman, E. S.; Rosai, J. |
| Article Title: | Comparing tumour staging and grading systems: A case study and a review of the issues, using thymoma as a model |
| Abstract: | We consider the problem of comparing alternative cancer staging and grading systems. Statistical comparisons are on the basis of the ability to predict survival, but more qualitative criteria, such as parsimony, and distinctive prognostic separability of the categories are relevant also. Furthermore, some staging systems are clearly ordinal, while others are not. Three candidate statistical measures are studied and compared: explained variation; area under the ROC curve; and the probability of concordance of stage and survival. Each of these has individual strengths and weaknesses. A data set involving the staging of thymoma is analysed in detail to motivate the problem and illustrate the results. Copyright (C) 2000 John Wiley and Sons, Ltd. |
| Keywords: | cancer survival; survival analysis; cancer staging; lymphatic metastasis; neoplasm staging; cancer grading; classification; prediction; time factors; data interpretation, statistical; thymus gland; problem solving; thymoma; thymus neoplasms; roc curve; cancer statistics; humans; prognosis; article |
| Journal Title: | Statistics in Medicine |
| Volume: | 19 |
| Issue: | 15 |
| ISSN: | 0277-6715 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2000-08-15 |
| Start Page: | 1997 |
| End Page: | 2014 |
| Language: | English |
| DOI: | 10.1002/1097-0258(20000815)19:15<1997::aid-sim511>3.0.co;2-c |
| PUBMED: | 10900448 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work