Efficient asymmetric synthesis of radicicol dimethyl ether: A novel application of ring-forming olefin metathesis Journal Article
| Authors: | Garbaccio, R. M.; Danishefsky, S. J. |
| Article Title: | Efficient asymmetric synthesis of radicicol dimethyl ether: A novel application of ring-forming olefin metathesis |
| Abstract: | (matrix presented) A concise, stereospecific synthesis of radicicol dimethyl ether is presented. The strategy relies on a convergent three-stage assembly of the 14-membered lactone which has, as a key transformation, a novel ring-forming metathesis reaction utilizing a vinyl epoxide. |
| Keywords: | chemistry; antibiotics, antineoplastic; antineoplastic antibiotic; macrolide; synthesis; indicators and reagents; radicicol; lactones; macrolides; lactone; dyes, reagents, indicators, markers and buffers; article |
| Journal Title: | Organic Letters |
| Volume: | 2 |
| Issue: | 20 |
| ISSN: | 1523-7060 |
| Publisher: | American Chemical Society |
| Date Published: | 2000-10-05 |
| Start Page: | 3127 |
| End Page: | 3129 |
| Language: | English |
| PUBMED: | 11009362 |
| PROVIDER: | scopus |
| DOI: | 10.1021/ol0063252 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
