Oral chemotherapeutic agents for colorectal cancer Journal Article
| Authors: | Sharma, S.; Saltz, L. B. |
| Article Title: | Oral chemotherapeutic agents for colorectal cancer |
| Abstract: | A number of novel oral chemotherapeutic agents are entering practice or are under development in the United States. Many of these agents display significant clinical activity against colorectal cancer. Many classes of compounds, including fluoropyrimidine analogs, dihydropyrimidine dehydrogenase (DPD) inhibitors, topoisomerase inhibitors, farnesyl transferase inhibitors, and others, are being developed for oral administration. This manuscript describes the progress of clinical development of these agents and also explores the relative merits and challenges of these approaches. Economic issues, patient preference, and patient selection issues surrounding oral chemotherapy for colorectal cancer will also be discussed. |
| Keywords: | cancer chemotherapy; patient satisfaction; fatigue; diarrhea; dose response; patient selection; antineoplastic agents; capecitabine; anorexia; colorectal cancer; mucosa inflammation; nausea; vomiting; drug effect; enzyme inhibitor; irinotecan; colorectal neoplasms; drug costs; colon cancer; protein farnesyltransferase inhibitor; tipifarnib; patient compliance; dna topoisomerase inhibitor; administration, oral; folinate calcium; fluoropyrimidine derivative; rectal cancer; 9 aminocamptothecin; uft; oral chemotherapy; economic analysis; lonafarnib; dihydropyrimidine dehydrogenase; rubitecan; humans; human; priority journal; article; 5 ethynyluracil; orzel |
| Journal Title: | The Oncologist |
| Volume: | 5 |
| Issue: | 2 |
| ISSN: | 1083-7159 |
| Publisher: | Oxford University Press |
| Date Published: | 2000-04-01 |
| Start Page: | 99 |
| End Page: | 107 |
| Language: | English |
| PUBMED: | 10794800 |
| PROVIDER: | scopus |
| DOI: | 10.1634/theoncologist.5-2-99 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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