Primary central nervous system lymphoma Journal Article

  


Author: Abrey, L. E.
Article Title: Primary central nervous system lymphoma
Abstract: BACKGROUND- Primary central nervous system lymphoma (PCNSL) is an uncommon primary brain tumor that is being diagnosed with increased frequency in both the immunocompetent population and the population infected with human immunodeficiency virus (HIV). REVlEW SUMMARY- PCNSL is an important diagnostic consideration in any patient with an enhancing lesion on neuroimaging, particularly in older adults and patients infected with HIV. Because this tumor has a propensity for widespread dissemination throughout the central nervous system, initial evaluation should include cerebrospinal fluid cytology and a slit lamp ophthalmologic examination. The addition of methotrexate-based chemotherapy to whole brain radiotherapy has improved disease control and long-term survival for patients diagnosed with PCNSL but may have significant associated neurologic toxicity for patients older than 60 years of age. CONCLUSIONS- The present challenge is to additionally improve the outcome of PCNSL patients, both in regards to disease control and treatment-related toxicity. To this end, several ongoing and planned studies are examining new therapeutic strategies for the treatment of PCNSL.
Keywords: cancer survival; treatment outcome; clinical feature; clinical trial; cisplatin; treatment planning; pathophysiology; radiation dose; chemotherapy; cytarabine; methotrexate; human immunodeficiency virus infection; antineoplastic agent; etoposide; differential diagnosis; dexamethasone; vincristine; diagnostic imaging; carmustine; lomustine; procarbazine; thiotepa; central nervous system tumor; symptom; lymphoma; comorbidity; methylprednisolone; cancer control; corticosteroid; cerebrospinal fluid cytology; brain lymphoma; slit lamp; neurologic complications; human; priority journal; article
Journal Title: The Neurologist
Volume: 6
Issue: 5
ISSN: 1074-7931
Publisher: Lippincott Williams & Wilkins  
Date Published: 2000-09-01
Start Page: 245
End Page: 254
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0033831503&partnerID=40&md5=8bde914dde5688059f86fff9ba539e1a
Notes: Export Date: 18 November 2015 -- Source: Scopus