A CBF-based event-related brain activation paradigm: Characterization of impulse-response function and comparison to BOLD Journal Article
| Authors: | Yang, Y.; Engelien, W.; Pan, H.; Xu, S.; Silbersweig, D. A.; Stern, E. |
| Article Title: | A CBF-based event-related brain activation paradigm: Characterization of impulse-response function and comparison to BOLD |
| Abstract: | A perfusion-based event-related functional MRI method for the study of brain activation is presented. In this method, cerebral blood flow (CBF) was measured using a recently developed multislice arterial spin-labeling (ASL) perfusion imaging method with rapid spiral scanning. Temporal resolution of the perfusion measurement was substantially improved by employing intertrial subtraction and stimulus-shifting schemes. Perfusion and blood oxygenation level-dependent (BOLD) signals were obtained simultaneously by subtracting or adding the control and labeled images, respectively, in the same data sets. The impulse response function (IRF) of perfusion during brain activation was characterized for multiple stimulus durations and compared to the simultaneously acquired BOLD response. The CBF response curve preceded the BOLD curve by 0.21 s in the rising phase and 0.64 s in the falling phase. Linear additivity of the CBF and BOLD responses was assessed with rapidly repeated stimulations within single trials, and departure from linearity was found in both responses, characterized as attenuated amplitude and delayed rising time. Event-related visual and sensorimotor activation experiments were successfully performed with the new perfusion technique. (C) 2000 Academic Press. |
| Keywords: | controlled study; magnetic resonance imaging; image analysis; oxygen; imaging system; brain; spin labels; brain mapping; image processing, computer-assisted; photic stimulation; nerve cell; brain blood flow; cerebrovascular circulation; technique; hemodynamics; normal human; human experiment; physical stimulation; cerebral blood flow; brain perfusion; spiral computer assisted tomography; evoked cortical response; stimulus response; fingers; visual cortex; sensorimotor function; visual stimulation; humans; human; priority journal; article; brain hemodynamic-neuronal response; brain perfusion imaging; event-related functional mri |
| Journal Title: | NeuroImage |
| Volume: | 12 |
| Issue: | 3 |
| ISSN: | 1053-8119 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2000-09-01 |
| Start Page: | 287 |
| End Page: | 297 |
| Language: | English |
| DOI: | 10.1006/nimg.2000.0625 |
| PUBMED: | 10944411 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
