Osteosarcoma associated with absent thumbs: A report of two cases Journal Article
| Authors: | Orme, L.; Gorlick, R.; Meyers, P. A.; Athanasian, E.; Huvos, A. G. |
| Article Title: | Osteosarcoma associated with absent thumbs: A report of two cases |
| Abstract: | An 8-year-old Hispanic boy with a hypoplastic left thumb, absent right thumb, and short stature experienced right leg pain and limp. A right tibial lesion was imaged and found to be osteosarcoma on biopsy. A 6-year-old Hispanic girl with congenitally absent thumbs experienced a pathologic fracture of her left femur after a minor sports injury. The radiologic abnormality seen was diagnosed as osteosarcoma on biopsy. Both patients continue to do well after intensive preoperative and postoperative high-dose chemotherapy and definitive reconstructive limb surgery. Osteosarcoma has been linked to several congenital syndromes in which absent thumbs are a feature. These two patients with absent thumbs and no definable syndrome experiencing osteosarcoma suggest that congenitally absent thumbs might be a risk factor for osteosarcoma in the absence of a syndrome. |
| Keywords: | osteosarcoma; cancer chemotherapy; child; bone neoplasms; cancer surgery; case report; plastic surgery; cisplatin; doxorubicin; methotrexate; risk factors; risk factor; ifosfamide; short stature; femur fracture; fanconi anemia; bone biopsy; thumb; pathologic fracture; finger malformation; humans; human; male; female; priority journal; article; rothmund-thomson syndrome; baller-gerold syndrome; hypoplastic-aplastic thumb; hand deformities, congenital |
| Journal Title: | Journal of Pediatric Hematology/Oncology |
| Volume: | 22 |
| Issue: | 1 |
| ISSN: | 1077-4114 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2000-01-01 |
| Start Page: | 73 |
| End Page: | 77 |
| Language: | English |
| DOI: | 10.1097/00043426-200001000-00014 |
| PUBMED: | 10695826 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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75Athanasian -
121Gorlick -
6
Orme -
311Meyers -
289
Huvos
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