Physical linkage of the lysyl oxidase-like (LOXL1) gene to the PML gene on human chromosome 15q22 Journal Article
| Authors: | Goy, A.; Gilles, F.; Remache, Y.; Zelenetz, A. D. |
| Article Title: | Physical linkage of the lysyl oxidase-like (LOXL1) gene to the PML gene on human chromosome 15q22 |
| Abstract: | A contig was constructed centered on the PML (promyelocytic leukemia) gene. Using an exon-trapping approach to identify potential genes from a pool of cosmids located 5' of the PML gene, four exons were identified that showed 100% sequence homology with the previously cloned lysyl oxydase-like (LOXL1) gene. An exon probe identified a single transcript of 2.4 kb on a multitissue Northern blot with a pattern identical to the one reported for the LOXL1 gene. Pulsed-field gel electrophoresis showed comigrating bands for both the PML cDNA and LOXL1 probes, demonstrating a physical linkage between these two genes. These data provide physical mapping information to complement the previous cytogenetic localization of LOXL1. Copyright (C) 2000 S. Karger AG, Basel. |
| Keywords: | human cell; exon; exons; neoplasm proteins; transcription factors; nuclear proteins; cloning, molecular; oncogene; dna; rna, messenger; tumor suppressor proteins; promyelocytic leukemia; sequence homology; sequence homology, nucleic acid; polymorphism, genetic; linkage (genetics); genetic linkage; normal human; complementary dna; pulsed field gel electrophoresis; electrophoresis, gel, pulsed-field; northern blotting; chromosome 15q; protein lysine 6 oxidase; chromosomes, human, pair 15; blotting, southern; humans; human; priority journal; article; cosmid; dna probe; contig; contig mapping; protein-lysine 6-oxidase |
| Journal Title: | Cytogenetics and Cell Genetics |
| Volume: | 88 |
| Issue: | 1-2 |
| ISSN: | 0301-0171 |
| Publisher: | S. Karger AG |
| Date Published: | 2000-01-01 |
| Start Page: | 22 |
| End Page: | 24 |
| Language: | English |
| PUBMED: | 10773658 |
| PROVIDER: | scopus |
| DOI: | 10.1159/000015477 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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