A calcitriol analogue, EB1089, inhibits the growth of LNCaP tumors in nude mice Journal Article
| Authors: | Blutt, S. E.; Polek, T. C.; Stewart, L. V.; Kattan, M. W.; Weigel, N. L. |
| Article Title: | A calcitriol analogue, EB1089, inhibits the growth of LNCaP tumors in nude mice |
| Abstract: | Limited options for the treatment of prostate cancer have spurred the search for new therapies. One innovative approach is the use of 1α,25- dihydroxyvitamin D3 (calcitriol) analogues to inhibit cancer growth. We demonstrate here that the calcitriol analogue, EB1089, extensively inhibits the growth of LNCaP prostate cancer cells in culture and causes the cells to both accumulate in G0-G1 and undergo apoptosis. Importantly, we found that EB1089 inhibits the growth of LNCaP tumor xenografts in nude mice. Because of these antiproliferative properties in vivo, EB1089 is a potential new therapeutic agent for the treatment of prostate cancer. |
| Keywords: | controlled study; nonhuman; antineoplastic agents; animal cell; mouse; animals; mice; cell cycle; apoptosis; tumor volume; calcium; calcitriol; antineoplastic activity; tumor cells, cultured; prostate cancer; prostatic neoplasms; cancer inhibition; mice, nude; cancer control; cell cycle g1 phase; cell cycle g0 phase; humans; male; priority journal; article; calcitriol derivative; seocalcitol |
| Journal Title: | Cancer Research |
| Volume: | 60 |
| Issue: | 4 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2000-02-15 |
| Start Page: | 779 |
| End Page: | 782 |
| Language: | English |
| PUBMED: | 10706079 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
