An immunotherapeutic approach to treatment of breast cancer: Focus on trastuzumab plus paclitaxel Journal Article
| Authors: | Gilewski, T.; Seidman, A.; Norton, L.; Hudis, C. |
| Article Title: | An immunotherapeutic approach to treatment of breast cancer: Focus on trastuzumab plus paclitaxel |
| Abstract: | Recent emphasis has focused on the development of an immunotherapeutic approach toward the treatment of breast cancer. In particular, evaluation of antibodies and vaccines are active areas of research. The monoclonal antibody trastuzumab (H), directed against the HER-2/neu protein, has resulted in inhibition of tumor growth in both preclinical and clinical studies. This effect can be increased when used in combination with several chemotherapeutic agents. A randomized trial of chemotherapy alone versus chemotherapy plus H in untreated metastatic breast cancer patients found prolonged survival in the combination therapy arm. Cardiac toxicity was increased with doxorubicin and cyclophosphamide plus H but not for paclitaxel (T) plus H. Several trials of dosedense weekly T have found minimal toxicity and significant clinical benefit. These findings prompted the initiation of a trial to evaluate weekly 1-h T plus weekly H. Preliminary data from this ongoing study demonstrate few side effects and a response rate of 64% (95%CI 42-76%). The optimal role of H in the treatment of breast cancer has not yet been defined. Additional evaluation in the metastatic and adjuvant settings is planned. |
| Keywords: | cancer survival; treatment outcome; major clinical study; clinical trial; drug tolerability; neutropenia; doxorubicin; drug efficacy; paclitaxel; cancer immunotherapy; phase 2 clinical trial; breast cancer; bone marrow suppression; antineoplastic combined chemotherapy protocols; cyclophosphamide; breast neoplasms; antibodies, monoclonal; immunotherapy; cardiotoxicity; phase 1 clinical trial; trastuzumab; clinical trials; humans; human; priority journal; article |
| Journal Title: | Cancer Chemotherapy and Pharmacology |
| Volume: | 46 |
| Issue: | 1 Suppl. |
| ISSN: | 0344-5704 |
| Publisher: | Springer |
| Date Published: | 2000-07-01 |
| Start Page: | S23 |
| End Page: | S26 |
| Language: | English |
| PUBMED: | 10950143 |
| PROVIDER: | scopus |
| DOI: | 10.1007/PL00014044 |
| DOI/URL: | |
| Notes: | Originally presented at the 15th Bristol-Myers Squibb Nagoya International Cancer Treatment Symposium, "New Immunological Approach to Cancer Treatment," 1999 Sep 10-11, Nagoya, Japan -- Export Date: 18 November 2015 -- Source: Scopus |
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