A comparative study between a calcium channel blocker (Nicardipine) and a combined α-β-blocker (Labetalol) for the control of emergence hypertension during craniotomy for tumor surgery Journal Article
| Authors: | Kross, R. A.; Ferri, E.; Leung, D.; Pratila, M.; Broad, C.; Veronesi, M.; Melendez, J. A. |
| Article Title: | A comparative study between a calcium channel blocker (Nicardipine) and a combined α-β-blocker (Labetalol) for the control of emergence hypertension during craniotomy for tumor surgery |
| Abstract: | We compared the efficacy of the combination of enalaprilat/labetalol with that of enalaprilat/nicardipine to prevent emergence postcraniotomy hypertension. A prospective, randomized open labeled clinical trial was designed to compare the incidence of breakthrough hypertension (systolic blood pressure [SBP] > 140 mm Hg) and adverse effects (hypotension, tachycardia, and bradycardia) between the two drug combinations. Secondarily, the effects of the drugs on SBP, mean blood pressure, and diastolic blood pressure were evaluated over the course of the study. Forty-two patients received enalaprilat 1.25 mg IV at dural closure followed by either multidose nicardipine 2 mg IV or labetalol 5 mg IV to maintain the SBP below 140 mm Hg. SBP was similarly controlled in both groups. There was a marginally smaller incidence of failures and adverse effects with labetalol. Blood pressure profiles were similar for both groups. |
| Keywords: | adult; clinical article; controlled study; treatment outcome; aged; middle aged; clinical trial; drug efficacy; hypertension; brain tumor; brain neoplasms; prospective study; prospective studies; controlled clinical trial; randomized controlled trial; incidence; bradycardia; hypotension; chi-square distribution; craniotomy; diastolic blood pressure; systolic blood pressure; blood pressure; analysis of variance; anesthetic recovery; beta adrenergic receptor blocking agent; calcium channel blocking agent; tachycardia; mean arterial pressure; alpha adrenergic receptor blocking agent; isoflurane; antihypertensive agents; angiotensin-converting enzyme inhibitors; labetalol; adrenergic beta-antagonists; calcium channel blockers; pancuronium; adrenergic alpha-antagonists; humans; human; male; female; priority journal; article; enalaprilat; nicardipine; nitrous oxide plus oxygen; anesthesia recovery period |
| Journal Title: | Anesthesia and Analgesia |
| Volume: | 91 |
| Issue: | 4 |
| ISSN: | 0003-2999 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2000-10-01 |
| Start Page: | 904 |
| End Page: | 909 |
| Language: | English |
| PUBMED: | 11004045 |
| PROVIDER: | scopus |
| DOI: | 10.1097/00000539-200010000-00024 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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