Small cell neuroendocrine carcinoma with skeletal muscle differentiation: Report of three cases Journal Article
| Authors: | Eusebi, V.; Damiani, S.; Pasquinelli, G.; Lorenzini, P.; Reuter, V. E.; Rosai, J. |
| Article Title: | Small cell neuroendocrine carcinoma with skeletal muscle differentiation: Report of three cases |
| Abstract: | Three cases of neuroendocrine carcinoma showing skeletal muscle differentiation are presented. The tumors were located in the skin and subcutaneous tissue, the urinary bladder, and the nasal cavity respectively, and were composed by two cell types admixed intimately with each other. One cell type had features identical to those seen in conventional small cell neuroendocrine carcinoma, including scanty cytoplasm, round nuclei with fine granular chromatin, immunohistochemical reactivity for neuron-specific enolase, chromogranin and cytokeratins, and electron-dense granules on ultrastructural examination. The second cell type was either plasmacytoid or elongated and straplike, with abundant eosinophilic cytoplasm and irregular nuclei with prominent nucleoli. These cells showed immunohistochemical positivity for desmin, sarcomeric actin, myoglobin, and myogenin. They also exhibited ultrastructural evidence of rhabdomyoblastic differentiation in the form of contractile filaments with abortive Z-band formation. An origin from a cell capable of dual differentiation toward neuroendocrine and rhabdomyoblastic elements is postulated for these tumors. |
| Keywords: | human tissue; protein expression; aged; clinical feature; histopathology; case report; myoglobin; skin neoplasms; tumor markers, biological; cell differentiation; urinary bladder neoplasms; neuroendocrine tumor; immunoenzyme techniques; sarcomatoid carcinoma; merkel cell carcinoma; rhabdomyosarcoma; cytokeratin; keratins; fatal outcome; chromogranin; nose neoplasms; skeletal muscle; desmin; myogenin; neuroendocrine carcinoma; small cell carcinoma; carcinoma, neuroendocrine; neuron specific enolase; muscle, skeletal; phosphopyruvate hydratase; cell ultrastructure; alpha actin; chromogranins; cytoplasmic granules; humans; human; male; female; article; myofilament |
| Journal Title: | American Journal of Surgical Pathology |
| Volume: | 24 |
| Issue: | 2 |
| ISSN: | 0147-5185 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2000-02-01 |
| Start Page: | 223 |
| End Page: | 230 |
| Language: | English |
| DOI: | 10.1097/00000478-200002000-00008 |
| PUBMED: | 10680890 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work