Multidisciplinary Treatment of Gastrointestinal Stromal Tumors Journal Article

   


Authors: Kingham, T. P.; DeMatteo, R. P.
Article Title: Multidisciplinary Treatment of Gastrointestinal Stromal Tumors
Abstract: Gastrointestinal stromal tumor (GIST) has been recognized as a unique tumor only in the last decade. Although rare as a clinical entity, there is much interest in the pathology and treatment because the KIT protooncogene mutation common to most GISTs can be inhibited by imatinib mesylate. Diagnosing and treating GIST requires a multidisciplinary approach, given the combination of pathologic and radiographic evaluation, surgical treatment, and oncologic care required to successfully treat patients with GIST. © 2009 Elsevier Inc. All rights reserved.
Keywords: immunohistochemistry; cancer chemotherapy; survival analysis; cancer surgery; gene mutation; mutation; clinical feature; clinical trial; fatigue; histopathology; review; cancer localization; cancer recurrence; doxorubicin; placebo; sunitinib; diarrhea; drug dose comparison; drug withdrawal; multimodality cancer therapy; antineoplastic agents; gemcitabine; cancer radiotherapy; combined modality therapy; treatment; temozolomide; cancer staging; nuclear magnetic resonance imaging; positron emission tomography; cancer diagnosis; diagnostic accuracy; gastrointestinal stromal tumor; imatinib; proto oncogene; gastrointestinal stromal tumors; proto-oncogene proteins c-kit; metastasis; computer assisted tomography; neoplasm recurrence, local; etoposide; nausea; molecular dynamics; dasatinib; pyrimidines; algorithms; cancer therapy; ifosfamide; abdominal pain; drug dose escalation; rash; diagnosis; positron-emission tomography; vatalanib; protein-tyrosine kinases; cancer epidemiology; piperazines; radiofrequency ablation; radiodiagnosis; everolimus; catheter ablation
Journal Title: Surgical Clinics of North America
Volume: 89
Issue: 1
ISSN: 0039-6109
Publisher: Elsevier Inc.  
Date Published: 2009-02-01
Start Page: 217
End Page: 233
Language: English
DOI: 10.1016/j.suc.2008.10.003
PUBMED: 19186237
PROVIDER: scopus
PMCID: PMC5010159
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-58749093957&partnerID=40&md5=609bb74b1c2528ce1ffb071701f077ce
Notes: --- - "Cited By (since 1996): 9" - "Export Date: 30 November 2010" - "CODEN: SCNAA" - "Source: Scopus"
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MSK Authors
  1. Ronald P DeMatteo
    637 DeMatteo
  2. T Peter Kingham
    609 Kingham
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