Updates on the management of gastrointestinal stromal tumors Journal Article
| Authors: | Bamboat, Z. M.; DeMatteo, R. P. |
| Article Title: | Updates on the management of gastrointestinal stromal tumors |
| Abstract: | Despite being the most common sarcoma of the gastrointestinal tract, gastrointestinal stromal tumor (GIST) has been widely recognized as a unique entity for just over a decade. The advent of tyrosine kinase inhibitors has revolutionized the diagnosis and treatment of GIST. Although surgery remains the only chance for cure, multimodal treatment that includes molecular therapy continues to develop. Optimal management of GIST requires careful radiographic, pathologic, medical, and surgical care, emphasizing the need for a multidisciplinary approach. This review highlights recent developments in the management of GIST. © 2012. |
| Keywords: | immunohistochemistry; overall survival; clinical feature; drug tolerability; fatigue; histopathology; review; sorafenib; placebo; sunitinib; artificial embolism; cancer risk; diarrhea; liver transplantation; drug targeting; cancer adjuvant therapy; positron emission tomography; follow up; cancer diagnosis; laparotomy; gastrointestinal stromal tumor; imatinib; progression free survival; computer assisted tomography; drug eruption; nausea; gene locus; dasatinib; mutational analysis; cancer resistance; abdominal pain; oncogene; survival time; contrast enhancement; vatalanib; surgery; skin discoloration; kit; nilotinib; radiofrequency ablation; tyrosine kinase; endoscopy; fluorodeoxyglucose; braf gene; recurrence free survival; oncogene c kit; cancer prognosis; dog1 gene; igfr1 gene; pdgfralpha gene; sdh gene |
| Journal Title: | Surgical Oncology Clinics of North America |
| Volume: | 21 |
| Issue: | 2 |
| ISSN: | 1055-3207 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-04-01 |
| Start Page: | 301 |
| End Page: | 316 |
| Language: | English |
| DOI: | 10.1016/j.soc.2011.12.004 |
| PROVIDER: | scopus |
| PUBMED: | 22365521 |
| PMCID: | PMC3386646 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 April 2012" - "CODEN: SOCAF" - "Source: Scopus" |
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