NCCN task force report: Update on the management of patients with gastrointestinal stromal tumors Journal Article
| Authors: | Demetri, G. D.; von Mehren, M.; Antonescu, C. R.; DeMatteo, R. P.; Ganjoo, K. N.; Maki, R. G.; Pisters, P. W. T.; Raut, C. P.; Riedel, R. F.; Schuetze, S.; Sundar, H. M.; Trent, J. C.; Wayne, J. D. |
| Article Title: | NCCN task force report: Update on the management of patients with gastrointestinal stromal tumors |
| Abstract: | The standard of care for managing patients with gastrointestinal stromal tumors (GISTs) rapidly changed after the introduction of effective molecularly targeted therapies involving tyrosine kinase inhibitors (TKIs), such as imatinib mesylate and sunitinib malate. A better understanding of the molecular characteristics of GISTs have improved the diagnostic accuracy and led to the discovery of novel immunomarkers and new mechanisms of resistance to TKI therapy, which in turn have resulted in the development of novel treatment strategies. To address these issues, the NCCN organized a task force consisting of a multidisciplinary panel of experts in the fields of medical oncology, surgical oncology, molecular diagnostics, and pathology to discuss the recent advances, identify areas of future research, and recommend an optimal approach to care for patients with GIST at all stages of disease. The task force met for the first time in October 2003 and again in December 2006 and October 2009. This supplement describes the recent developments in the field of GIST as discussed at the October 2009 meeting. © Journal of the National Comprehensive Cancer Network. |
| Keywords: | immunohistochemistry; cancer chemotherapy; treatment response; cancer surgery; acute granulocytic leukemia; gene mutation; overall survival; clinical feature; clinical trial; disease course; fatigue; histopathology; neutropenia; review; cancer recurrence; sorafenib; fluorouracil; placebo; sunitinib; advanced cancer; diarrhea; drug dose comparison; drug dose reduction; drug withdrawal; gastrointestinal hemorrhage; hypertension; hypophosphatemia; side effect; antineoplastic agents; drug megadose; positron emission tomography; follow up; anorexia; gastrointestinal stromal tumor; pdgfra; imatinib; stem cell factor; carney complex; gastrointestinal stromal tumors; edema; metastasis; progression free survival; computer assisted tomography; lung toxicity; gene expression profiling; anemia; bone marrow suppression; tumor volume; gastrointestinal symptom; leukopenia; mucosa inflammation; nausea; thrombocytopenia; vomiting; midazolam; differential diagnosis; tumor markers, biological; hemoglobin blood level; diagnostic imaging; dasatinib; pyrimidines; wild type; prediction; tyrosine kinase inhibitors; abdominal pain; drug dose escalation; febrile neutropenia; rash; chronic disease; malaise; patient care; depression; liver metastasis; disease severity; myelodysplastic syndrome; contrast enhancement; cardiotoxicity; fluorodeoxyglucose f 18; warfarin; patient compliance; drug clearance; nausea and vomiting; stomach cancer; contrast medium; skin discoloration; cyanocobalamin deficiency; blood cell count; drug blood level; maximum tolerated dose; kit; piperazines; dna mutational analysis; ketoconazole; heart arrhythmia; hypothyroidism; iron deficiency; gastrointestinal tract; gist; nilotinib; indoles; pyrroles; dyspepsia; hand foot syndrome; rifampicin; congestive heart failure; phenytoin; pediatrics; fluid retention; itraconazole; muscle cramp; tanespimycin hydroquinone; cd117; weight; loose feces; thyrotropin blood level; acute coronary syndrome; platelet derived growth factor a; hypericum perforatum extract; abdominal tumor; gastric mass; small bowel tumor; nccn; gep; tkis; wild-type gists; grapefruit extract; pomegranate extract; folic acid deficiency |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 8 |
| Issue: | Suppl. 2 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2010-04-01 |
| Start Page: | S1 |
| End Page: | S41 |
| Language: | English |
| PUBMED: | 20457867 |
| PROVIDER: | scopus |
| PMCID: | PMC4103754 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 49" - "Export Date: 28 June 2012" - "Source: Scopus" |
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