Do not scratch that mole! Journal Article
| Authors: | Jelcic, M.; Niethammer, P. |
| Article Title: | Do not scratch that mole! |
| Abstract: | Nevi harbor some of the same oncogene mutations that also drive malign melanoma. Further tumor promoting events are required to unleash their carcinogenic potential. Using zebrafish whose melanocytes overexpress an HRAS-oncogene, a new study reports that injury induces melanoma, possibly through recruitment of neutrophils that trigger proliferation of preneoplastic melanocytes. © 2015 Elsevier Ltd. |
| Keywords: | unclassified drug; nonhuman; cell proliferation; gene overexpression; melanoma; melanocyte; tissue regeneration; oncogene h ras; carcinogenesis; wound healing; wound; oncogene; neutrophil; carcinogenicity; experimental melanoma; reactive oxygen metabolite; short survey; innate immunity; ras protein; papilloma; macrophage; injury; zebra fish; h ras protein |
| Journal Title: | Trends in Immunology |
| Volume: | 36 |
| Issue: | 9 |
| ISSN: | 1471-4906 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2015-09-01 |
| Start Page: | 503 |
| End Page: | 504 |
| Language: | English |
| DOI: | 10.1016/j.it.2015.07.008 |
| PROVIDER: | scopus |
| PMCID: | PMC4567386 |
| PUBMED: | 26254146 |
| DOI/URL: | |
| Notes: | Export Date: 2 October 2015 -- Source: Scopus |
