Oncogenes in melanoma Journal Article
| Authors: | Polsky, D.; Cordon-Cardo, C. |
| Article Title: | Oncogenes in melanoma |
| Abstract: | Transformation of normal melanocytes into melanoma cells is accomplished by the activation of growth stimulatory pathways, typically leading to cellular proliferation, and the inactivation of apoptotic and tumor suppressor pathways. Small molecule inhibitors of proteins in the growth stimulatory pathways are under active investigation, and their application to melanoma patients would represent a new treatement strategy to inhibit cell proliferation or induce cell death. We provide a general overview of the mechanisms of oncogene activation and the functions of oncogenes. Lastly, we review oncogenic events in melanoma. |
| Keywords: | signal transduction; epidermal growth factor; mitogen activated protein kinase; platelet derived growth factor; proto-oncogene proteins; review; raf protein; cell proliferation; cell death; melanoma; apoptosis; stress activated protein kinase; epidermal growth factor receptor; gene function; platelet derived growth factor receptor; nuclear proteins; oncogenes; cancer inhibition; oncogene; gene activation; gene expression regulation, neoplastic; cell transformation; genes, myc; ras protein; cell nucleus; somatomedin c; ras proteins; oncogene k ras; proliferation; cyclin d1; oncogene c myc; malignant transformation; cyclin-dependent kinases; growth factor; guanine nucleotide binding protein; oncogene c myb; proto-oncogene proteins c-bcl-2; oncogene myc; proto-oncogene proteins b-raf; somatomedin b; cyclin dependent kinase 4; proto-oncogene proteins c-mdm2; transformation; cyclin-dependent kinase 4; receptors, growth factor; proto-oncogene proteins c-raf; growth substances; protein kinase p60; basic fibroblast growth factor; fibroblast growth factor receptor; protein fos; humans; human; priority journal; double minute chromosome |
| Journal Title: | Oncogene |
| Volume: | 22 |
| Issue: | 20 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2003-05-19 |
| Start Page: | 3087 |
| End Page: | 3091 |
| Language: | English |
| DOI: | 10.1038/sj.onc.1206449 |
| PUBMED: | 12789285 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
