Genetics and immunology: Reinvigorated Journal Article
| Authors: | Snyder, A.; Makarov, V.; Hellmann, M.; Rizvi, N.; Merghoub, T.; Wolchok, J. D.; Chan, T. A. |
| Article Title: | Genetics and immunology: Reinvigorated |
| Abstract: | Immune checkpoint blockade therapy is changing oncology by improving the outcome of patients with advanced malignancies. Our research has revealed the genetic features of tumors present in patients who initiate a successful antitumor immune response and derive clinical benefit from immune checkpoint blockade therapy versus non-responders. © 2015 Taylor & Francis Group, LLC. |
| Keywords: | somatic mutation; mutation; cancer growth; genetic analysis; biomarkers; cytotoxic t lymphocyte antigen 4 antibody; cancer immunotherapy; antineoplastic activity; high throughput screening; cancer genetics; t lymphocyte receptor; immunology; immune response; immunotherapy; immunogenicity; genomics; ctla-4; pd-1; programmed death 1 ligand 1; dna directed dna polymerase beta; tumor invasion; cancer; human; article; pembrolizumab; immunomonitoring; new targets |
| Journal Title: | OncoImmunology |
| Volume: | 4 |
| Issue: | 10 |
| ISSN: | 2162-4011 |
| Publisher: | Landes Bioscience |
| Date Published: | 2015-01-01 |
| Start Page: | e1029705 |
| Language: | English |
| DOI: | 10.1080/2162402x.2015.1029705 |
| PROVIDER: | scopus |
| PMCID: | PMC4589040 |
| PUBMED: | 26451299 |
| DOI/URL: | |
| Notes: | Export Date: 2 October 2015 -- Source: Scopus |
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