Functions and regulation of the multitasking FANCM family of DNA motor proteins Journal Article
| Authors: | Xue, X.; Sung, P.; Zhao, X. |
| Article Title: | Functions and regulation of the multitasking FANCM family of DNA motor proteins |
| Abstract: | Members of the conserved FANCM family of DNA motor proteins play key roles in genome maintenance processes. FANCM supports genome duplication and repair under different circumstances and also functions in the ATRmediated DNA damage checkpoint. Some of these roles are shared among lower eukaryotic family members. Human FANCM has been linked to Fanconi anemia, a syndrome characterized by cancer predisposition, developmental disorder, and bone marrow failure. Recent studies on human FANCM and its orthologs from other organisms have provided insights into their biological functions, regulation, and collaboration with other genome maintenance factors. This review summarizes the progress made, with the goal of providing an integrated view of the functions and regulation of these enzymes in humans and model organisms and how they advance our understanding of genome maintenance processes. © 2015 Xue et al. |
| Keywords: | unclassified drug; dna binding protein; nonhuman; dna replication; dna synthesis; protein function; cancer susceptibility; protein dna binding; protein; regulatory mechanism; saccharomyces cerevisiae; histone; double stranded dna break; stress; genome; dna structure; drosophila melanogaster; developmental disorder; phosphotransferase; dna cross linking; rad51 protein; fanconi anemia; schizosaccharomyces pombe; dna denaturation; bone marrow depression; dna template; dna damage checkpoint; orthology; bloom syndrome helicase; molecular motor; mph1; arabidopsis thaliana; blm; holliday junction; recombination repair; human; priority journal; article; replication fork regression; fancm; crossover control; fml1; mhf; fa associated protein 24; protein fancm; protein rmi; protein smc5; protein smc6; topoisomerase iiialpha |
| Journal Title: | Genes and Development |
| Volume: | 29 |
| Issue: | 17 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2015-09-01 |
| Start Page: | 1777 |
| End Page: | 1788 |
| Language: | English |
| DOI: | 10.1101/gad.266593.115 |
| PROVIDER: | scopus |
| PMCID: | PMC4573851 |
| PUBMED: | 26341555 |
| DOI/URL: | |
| Notes: | Export Date: 2 October 2015 -- Source: Scopus |
