Appearance of untreated bone metastases from breast cancer on FDG PET/CT: Importance of histologic subtype Journal Article
| Authors: | Dashevsky, B. Z.; Goldman, D. A.; Parsons, M.; Gönen, M.; Corben, A. D.; Jochelson, M. S.; Hudis, C. A.; Morrow, M.; Ulaner, G. A. |
| Article Title: | Appearance of untreated bone metastases from breast cancer on FDG PET/CT: Importance of histologic subtype |
| Abstract: | Purpose: To determine if the histology of a breast malignancy influences the appearance of untreated osseous metastases on FDG PET/CT. Methods: This retrospective study was performed under IRB waiver. Our Hospital Information System was screened for breast cancer patients who presented with osseous metastases, who underwent FDG PET/CT prior to systemic therapy or radiotherapy from 2009 to 2012. Patients with invasive ductal carcinoma (IDC), invasive lobular carcinoma (ILC), or mixed ductal/lobular (MDL) histology were included. Patients with a history of other malignancies were excluded. PET/CT was evaluated, blinded to histology, to classify osseous metastases on a per-patient basis as sclerotic, lytic, mixed lytic/sclerotic, or occult on CT, and to record SUVmax for osseous metastases on PET. Results: Following screening, 95 patients who met the inclusion criteria (74 IDC, 13 ILC, and 8 MDL) were included. ILC osseous metastases were more commonly sclerotic and demonstrated lower SUVmax than IDC metastases. In all IDC and MDL patients with osseous metastases, at least one was FDG-avid. For ILC, all patients with lytic or mixed osseous metastases demonstrated at least one FDG-avid metastasis; however, in only three of seven patients were sclerotic osseous metastases apparent on FDG PET. Conclusion: The histologic subtype of breast cancer affects the appearance of untreated osseous metastases on FDG PET/CT. In particular, non-FDG-avid sclerotic osseous metastases were more common in patients with ILC than in patients with IDC. Breast cancer histology should be considered when interpreting non-FDG-avid sclerotic osseous lesions on PET/CT, which may be more suspicious for metastases (rather than benign lesions) in patients with ILC. © 2015, Springer-Verlag Berlin Heidelberg. |
| Keywords: | adult; controlled study; human tissue; aged; major clinical study; systemic therapy; bone metastasis; cancer radiotherapy; follow up; breast cancer; retrospective study; electronic medical record; breast carcinoma; fluorodeoxyglucose f 18; computer assisted emission tomography; pet/ct; ductal; bone biopsy; osseous metastases; lobular; human; female; article; pet-ct scanner |
| Journal Title: | European Journal of Nuclear Medicine and Molecular Imaging |
| Volume: | 42 |
| Issue: | 11 |
| ISSN: | 1619-7070 |
| Publisher: | Springer |
| Date Published: | 2015-10-01 |
| Start Page: | 1666 |
| End Page: | 1673 |
| Language: | English |
| DOI: | 10.1007/s00259-015-3080-z |
| PROVIDER: | scopus |
| PMCID: | PMC4558334 |
| PUBMED: | 25971426 |
| DOI/URL: | |
| Notes: | Export Date: 2 October 2015 -- Source: Scopus |
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