When rejuvenation is a problem: Challenges of modeling late-onset neurodegenerative disease Journal Article

   


Authors: Vera, E.; Studer, L.
Article Title: When rejuvenation is a problem: Challenges of modeling late-onset neurodegenerative disease
Abstract: In contrast to the successful modeling of early-onset disorders using patient-specific cells, modeling of late-onset neurodegenerative diseases such as Parkinson’s disease remains a challenge. This might be related to the often ignored fact that current induced pluripotent stem cell (iPSC) differentiation protocols yield cells that typically show the behavior of fetal stage cells. Acknowledging aging as a contributing factor in late-onset neurodegenerative disorders represents an important step on the road towards faithfully recreating these diseases in vitro. Here, we summarize progress in the field and review the strategies and challenges for triggering late-onset disease phenotypes. © 2015, Published by The Company of Biologists Ltd.
Keywords: human cell; disease course; nonhuman; phenotype; disease model; aging; fetus; parkinson disease; rejuvenation; degenerative disease; molecular model; nuclear reprogramming; disease modeling; human; priority journal; article
Journal Title: Development
Volume: 142
Issue: 18
ISSN: 0950-1991
Publisher: Company of Biologists  
Date Published: 2015-09-15
Start Page: 3085
End Page: 3089
Language: English
DOI: 10.1242/dev.120667
PROVIDER: scopus
PUBMED: 26395137
PMCID: PMC6514401
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84942162882&partnerID=40&md5=65c9f467ae6645b6d2d7b722a4a09e7d
Notes: Export Date: 2 October 2015 -- Source: Scopus
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MSK Authors
  1. Lorenz Studer
    220 Studer
  2. Elsa Vera
    5 Vera
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