Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants Journal Article

   


Authors: Fernández-Tejada, A.; Tan, D. S.; Gin, D. Y.
Article Title: Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants
Abstract: We describe a new, versatile synthetic approach to Quillaja saponin variants based on the natural product immunoadjuvant QS-21. This modular, divergent strategy provides efficient access to linear oligosaccharide domain variants with modified sugars and regiochemistries. This new synthetic approach opens the door to the rapid generation of diverse analogues to identify novel saponin adjuvants with improved synthetic accessibility. © The Royal Society of Chemistry 2015.
Keywords: unclassified drug; drug synthesis; glycosylation; immunological adjuvant; deacetylation; oligosaccharide; acylation; qs 21; hydrogenolysis; article; quillaja saponin; quillaja saponin vaccine adjuvant; sqs 1 0 10 18; sqs 1 0 11 18; sqs 1 0 12 18
Journal Title: Chemical Communications
Volume: 51
Issue: 73
ISSN: 1359-7345
Publisher: Royal Society of Chemistry  
Date Published: 2015-09-21
Start Page: 13949
End Page: 13952
Language: English
DOI: 10.1039/c5cc05244k
PROVIDER: scopus
PUBMED: 26243268
PMCID: PMC4643164
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84940545329&partnerID=40&md5=db1fe224d5a7bea2984beb78c5ffe0b1
Notes: Export Date: 2 October 2015 -- Source: Scopus
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MSK Authors
  1. Derek S Tan
    92 Tan
  2. David Y Gin
    41 Gin
  3. Alberto Fernandez-Tejada
    17 Fernandez-Tejada
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