Synthesis of QS-21-xylose: Establishment of the immunopotentiating activity of synthetic QS-21 adjuvant with a melanoma vaccine Journal Article
| Authors: | Deng, K.; Adams, M. M.; Damani, P.; Livingston, P. O.; Ragupathi, G.; Gin, D. Y. |
| Article Title: | Synthesis of QS-21-xylose: Establishment of the immunopotentiating activity of synthetic QS-21 adjuvant with a melanoma vaccine |
| Abstract: | (Chemical Equation Presented) A helping hand: The adjuvant QS-21-xylose (see structure; the xylose residue is shown in red) was obtained in pure form by chemical synthesis. When combined with its synthetic apiose isomer to furnish synthetic QS-21 (sQS-21), the saponin combination was shown to aid the production of antibodies in mice when injected with a melanoma vaccine. The preparation of sQS-21 provides access to pure, functional saponin adjuvants of defined composition. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA. |
| Keywords: | mouse; animal; animals; mice; skin neoplasms; mice, inbred c57bl; c57bl mouse; skin tumor; immunology; chemistry; cancer vaccine; cancer vaccines; glycosylation; experimental melanoma; melanoma, experimental; immunological adjuvant; adjuvants, immunologic; chemical reactions; synthesis; total synthesis; synthesis (chemical); antibody formation; antibody production; vaccines; complexation; saponins; amides; amide; adjuvants; qs 21; gangliosides; ganglioside; natural products; saponin; ganglioside gd3 amide congener; qs 21 xylose; qs-21-xylose |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 47 |
| Issue: | 34 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2008-01-01 |
| Start Page: | 6395 |
| End Page: | 6398 |
| Language: | English |
| DOI: | 10.1002/anie.200801885 |
| PUBMED: | 18624313 |
| PROVIDER: | scopus |
| PMCID: | PMC2602848 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 13" - "Export Date: 17 November 2011" - "CODEN: ACIEA" - "Source: Scopus" |
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