Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes Conference Paper

  


Authors: Lenshof, A.; Magnusson, C.; Augustsson, P.; Haflidadottir, B.; Lilja, H.; Laurell, T.
Title: Improved acoustophoretic circulating tumor cell (CTC) separation for low target cell numbers in clinical volumes
Conference Title: 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Abstract: We present an improved acoustophoretic system for circulating tumor cell separation from blood. The system is operated by pressure driven flow, including flow sensors and a feed-back loop for precise flow control. The pressure driven system provides a user interface that can be handled by a non-skilled operator, and most importantly full clinical samples of 7 mL can be processed in 70 minutes. The improved flow control enables recovery of rare tumor cell populations ≈10 cells/mL spiked in whole blood at a recovery close to 100%. © 14CBMS.
Keywords: cell proliferation; cytology; blood; cell culture; tumors; molecular biology; circulating tumor cells; acoustophoresis; separation; tumor cells; cells; feed-back loop; user interfaces; temperature control; cancer; circulation tumor cells; rare cell; flow control; clinical samples; pressure-driven; pressure-driven flows
Journal Title Proceedings of the 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Conference Dates: 2014 Oct 26-30
Conference Location: San Diego, CA
ISBN: 978-0-9798064-7-6
Publisher: Chemical and Biological Microsystems Society  
Date Published: 2014-01-01
Start Page: 594
End Page: 596
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84941687206&partnerID=40&md5=952c0126008a5f4a41a68fbae6ccd61a
Notes: Conference Paper: T.079a -- Source: Scopus