Use of an artificial lymphatic system during carboplatin infusion to improve canine osteosarcoma blood flow and clinical response Journal Article


Authors: DiResta, G. R.; Aiken, S. W.; Brown, H. K.; Bergman, P. J.; Hohenhaus, A.; Ehrhart, E. J.; Baer, K.; Healey, J. H.
Article Title: Use of an artificial lymphatic system during carboplatin infusion to improve canine osteosarcoma blood flow and clinical response
Abstract: Background: The artificial lymphatic system (ALS), a mechanical system designed to reduce increased interstitial fluid pressure in solid tumors and enhance the delivery of chemotherapy, was evaluated within a randomized clinical trial treating spontaneously occurring canine appendicular osteosarcoma (OS), a tumor similar to its human OS counterpart. Methods: An ALS was investigated for its ability to increase OS blood flow and increase uptake of intravenously administered carboplatin. Results: Blood flow increased by 314% in tumors with active ALS drains versus 126% in control tumors (P < .03). Tumor carboplatin uptake increased by 51% after drain activation (P = .07). Microvascular density (MVD) was measured in tumors after surgical amputation and in corresponding bone regions in a cohort of normal dogs. The OS tumors had equivalent MVD as normal bone, and MVD was higher in the humerus than the femur (P < .03) in both tumor and normal bone. Median survival between the ALS-treated and control cohorts was not different despite increased drug uptake or ALS manipulation. Compared with historic controls, ALS drain insertion into tumors to reduce interstitial fluid pressure did not worsen the prognosis. Conclusions: The findings in canine spontaneously occurring OS indicate that an ALS may be of value as a chemotherapy adjunct for enhancing the delivery of chemotherapy to tumor interstitium. © 2007 Society of Surgical Oncology.
Keywords: osteosarcoma; cancer survival; controlled study; treatment outcome; treatment response; bone neoplasms; survival analysis; humerus; nonhuman; antineoplastic agents; animals; carboplatin; cohort studies; oxygen; animal experiment; animal model; biopsy; lymphatic system; drug uptake; dog; dog diseases; dogs; bone; blood flow; femur; infusions, intravenous; microvascularization; regional blood flow; canine; microvessel density; artificial lymphatic system; interstitial fluid pressure; artificial organ; mechanical lymphatic system; artificial organs
Journal Title: Annals of Surgical Oncology
Volume: 14
Issue: 8
ISSN: 1068-9265
Publisher: Springer  
Date Published: 2007-08-01
Start Page: 2411
End Page: 2421
Language: English
DOI: 10.1245/s10434-007-9373-0
PUBMED: 17503157
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "CODEN: ASONF" - "Source: Scopus"
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  1. Holly K Brown
    5 Brown
  2. John H Healey
    470 Healey