Mechanisms of epithelial wound detection Journal Article


Authors: Enyedi, B.; Niethammer, P.
Article Title: Mechanisms of epithelial wound detection
Abstract: Efficient wound healing requires the coordinated responses of various cell types within an injured tissue. To react to the presence of a wound, cells have to first detect it. Judging from their initial biochemical and morphological responses, many cells including leukocytes, epithelial cells, and endothelial cells detect wounds from over hundreds of micrometers within seconds-to-minutes. Wound detection involves the conversion of an injury-induced homeostatic perturbation, such as cell lysis, an unconstrained epithelial edge, or permeability barrier breakdown, into a chemical or physical signal. The signal is spatially propagated through the tissue to synchronize protective responses of cells near the wound site and at a distance. This review summarizes the triggers and mechanisms of wound detection in animals. © 2015 Elsevier Ltd.
Keywords: signal transduction; review; nonhuman; animalia; wound; cytolysis; tissue level; cell stress; human; priority journal; epithelial wound; wound detection
Journal Title: Trends in Cell Biology
Volume: 25
Issue: 7
ISSN: 0962-8924
Publisher: Elsevier Inc.  
Date Published: 2015-07-01
Start Page: 398
End Page: 407
Language: English
DOI: 10.1016/j.tcb.2015.02.007
PROVIDER: scopus
PMCID: PMC4475481
PUBMED: 25813429
DOI/URL:
Notes: Export Date: 2 September 2015 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Balazs Gabor Enyedi
    9 Enyedi