High-resolution genomic analysis: The tumor-immune interface comes into focus Journal Article
| Authors: | Havel, J. J.; Chan, T. A. |
| Article Title: | High-resolution genomic analysis: The tumor-immune interface comes into focus |
| Abstract: | A genomic analysis of heterogeneous colorectal tumor samples has uncovered interactions between immunophenotype and various aspects of tumor biology, with implications for informing the choice of immunotherapies for specific patients and guiding the design of personalized neoantigen-based vaccines. © 2015 Havel and Chan; licensee BioMed Central. |
| Keywords: | cancer survival; overall survival; cancer staging; genetic analysis; colorectal cancer; tumor associated leukocyte; phenotype; cancer immunotherapy; gene expression; cell infiltration; tumor volume; tumor antigen; cancer genetics; genome analysis; regulatory t lymphocyte; colorectal tumor; tumor immunity; tumor growth; cytotoxic t lymphocyte antigen 4; immunosuppressive treatment; immunocompetent cell; suppressor cell; programmed death 1 receptor; cancer immunology; tumor escape; antigenicity; chemokine receptor ccr8; myeloid derived suppressor cell; human; article; b cell maturation antigen; gene set enrichment analysis |
| Journal Title: | Genome Biology |
| Volume: | 16 |
| ISSN: | 1465-6906 |
| Publisher: | Biomed Central Ltd |
| Date Published: | 2015-03-01 |
| Start Page: | 65 |
| Language: | English |
| DOI: | 10.1186/s13059-015-0631-3 |
| PROVIDER: | scopus |
| PMCID: | 4377855 |
| PUBMED: | 25853850 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
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