Merkel cell carcinoma: Histologic features and prognosis Journal Article
| Authors: | Andea, A. A.; Coit, D. G.; Amin, B.; Busam, K. J. |
| Article Title: | Merkel cell carcinoma: Histologic features and prognosis |
| Abstract: | BACKGROUND. Currently, little is known regarding the potential prognostic value of histologic features in primary cutaneous neuroendocrine (Merkel cell) carcinomas (MCC). METHODS. In a retrospective review of the tumor histology and clinical outcome data (median follow-up, 51 months; range, 3-224 months) of 156 patients with a diagnosis of MCC, the following histologic features were evaluated: tumor thickness, tumor size (greatest dimension of the tumor), microanatomic compartment involved by tumor (dermis and/or subcutis and/or deeper), tumor growth pattern (nodular circumscribed vs infiltrative), lymphovascular invasion (LVI), tumor-infiltrating lymphocytes, tumor necrosis, ulceration, and solar elastosis. RESULTS. The overall 5-year survival rate was 67.5%. On univariate analysis, parameters that were associated significantly with survival were tumor thickness (P = .001), tumor size (P = .0002), deepest anatomic compartment involved by tumor (P = .0003), tumor growth pattern (P = .003), LVI (P < .00001), tumor-infiltrating lymphocytes (P = .05), and solar elastosis (P = .04). On multivariate analysis, the presence of a nodular growth pattern, low tumor depth, and absence of LVI were associated with longer survival. CONCLUSIONS. In addition to the known prognostic value of tumor stage, 3 histologic features were identified to have prognostic significance: tumor thickness (depth of tumor invasion), the presence of LVI, and tumor growth pattern. © 2008 American Cancer Society. |
| Keywords: | survival; adult; controlled study; human tissue; aged; aged, 80 and over; middle aged; survival rate; retrospective studies; major clinical study; clinical feature; histopathology; cancer staging; outcome assessment; lymph nodes; lymphatic metastasis; neoplasm staging; tumor associated leukocyte; lymphocytes, tumor-infiltrating; skin neoplasms; tumor volume; cancer invasion; cutaneous; carcinoma; merkel cell tumor; carcinoma, merkel cell; neoplasm invasiveness; tumor growth; cancer morphology; ulcer; neuroendocrine; tumor necrosis; elastosis; merkel cell; histologic parameters |
| Journal Title: | Cancer |
| Volume: | 113 |
| Issue: | 9 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 2008-11-01 |
| Start Page: | 2549 |
| End Page: | 2558 |
| Language: | English |
| DOI: | 10.1002/cncr.23874 |
| PUBMED: | 18798233 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 29" - "Export Date: 17 November 2011" - "CODEN: CANCA" - "Source: Scopus" |
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