Altered cytokine and chemokine profiles in multiple myeloma and its precursor disease Journal Article
| Authors: | Zingone, A.; Wang, W.; Corrigan-Cummins, M.; Wu, S. P.; Plyler, R.; Korde, N.; Kwok, M.; Manasanch, E. E.; Tageja, N.; Bhutani, M.; Mulquin, M.; Zuchlinski, D.; Yancey, M. A.; Roschewski, M.; Zhang, Y.; Roccaro, A. M.; Ghobrial, I. M.; Calvo, K. R.; Landgren, O. |
| Article Title: | Altered cytokine and chemokine profiles in multiple myeloma and its precursor disease |
| Abstract: | Currently, no reliable biomarkers are available to predict transformation from smoldering myeloma (SMM) to multiple myeloma (MM). Using an ultrasensitive enzyme-linked immunosorbent assay (ELISA) we assessed the levels of a broad range of cytokines and chemokines in the peripheral blood (PB) and bone marrow (BM) supernatant collected from 14 SMM and 38 MM patients and compared to healthy donors. We found significantly increased levels of key cytokines, in particular CXCL8 (IL-8), associated with progressive disease state (controls → SMM → MM). Cytokine profiles were found similar in PB and BM. Five of fourteen SMM patients (36%) progressed to MM.Our findings, although based on a limited number of patients, suggest that serum-based cytokines may have a future role as biomarkers for disease progression and could potentially be assessed as novel targets for treatment. © 2014. |
| Keywords: | signal transduction; controlled study; major clinical study; myeloproliferative disorder; disease course; pathogenesis; protein function; biological marker; protein analysis; protein blood level; disease association; interleukin 2; multiple myeloma; bone marrow; interleukin 10; interleukin 12p70; interleukin 13; interleukin 1beta; interleukin 4; interleukin 5; interleukin 8; enzyme linked immunosorbent assay; cytokine; chemokine; tumor necrosis factor alpha; gamma interferon; blood analysis; interleukin 6; tumor growth; chemokines; smoldering multiple myeloma; human; priority journal; article; cxcl8 |
| Journal Title: | Cytokine |
| Volume: | 69 |
| Issue: | 2 |
| ISSN: | 1043-4666 |
| Publisher: | Academic Press, Elsevier Inc |
| Date Published: | 2014-10-01 |
| Start Page: | 294 |
| End Page: | 297 |
| Language: | English |
| DOI: | 10.1016/j.cyto.2014.05.017 |
| PROVIDER: | scopus |
| PMCID: | PMC4148078 |
| PUBMED: | 25043675 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2015 -- Source: Scopus |
